Tubb4a - tubulin, beta 4A class IVA Gene

Predicted to enable GTP binding activity and calcium ion binding activity. Predicted to be a structural constituent of Cytoskeleton. Predicted to be involved in microtubule Cytoskeleton organization; mitotic cell cycle; and negative regulation of microtubule polymerization. Predicted to act upstream of or within cell projection organization. Located in several cellular components, including internode region of axon; myelin sheath; and neuronal cell body. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study hypomyelinating leukodystrophy 6. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 6 and torsion dystonia 4. Orthologous to human TUBB4A (tubulin beta 4A class IVa). [provided by Alliance of Genome Resources, Apr 2022]