Ucp3 - uncoupling protein 3 (mitochondrial, proton carrier) Gene

Also Known as UCP-3; Slc25a9

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22229

Summary

Enables Oxidative Phosphorylation uncoupler activity. Acts upstream of or within fatty acid metabolic process and response to superoxide. Located in mitochondrion. Is expressed in adipose tissue; heart; and skeletal muscle. Human ortholog(s) of this gene implicated in coronary restenosis; diabetic neuropathy; glucose metabolism disease (multiple); and obesity. Orthologous to human UCP3 (uncoupling protein 3). [provided by Alliance of Genome Resources, Apr 2022]

Ucp3 Products (1)

mRNA Protein Name
NM_009464.3 NP_033490.1 mitochondrial uncoupling protein 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
NOT enables oxidative phosphorylation uncoupler activity IMP
IMP: Inferred from mutant phenotype
11707458 MGI
enables oxidative phosphorylation uncoupler activity IMP
IMP: Inferred from mutant phenotype
10748195 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
26915802 MGI
enables proton transmembrane transporter activity IDA
IDA: Inferred from direct assay
29212043 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within fatty acid metabolic process IMP
IMP: Inferred from mutant phenotype
10748196 MGI
involved in lipid hydroperoxide transport IMP
IMP: Inferred from mutant phenotype
20363757 MGI
involved in proton transmembrane transport IDA
IDA: Inferred from direct assay
29212043 MGI
acts upstream of or within response to superoxide IMP
IMP: Inferred from mutant phenotype
11780125 MGI
Cellular Component GO Annotation Evidence References Source
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
26915802 MGI
located in mitochondrion IMP
IMP: Inferred from mutant phenotype
11707458 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mitochondrial uncoupling protein 3

  • solute carrier family 25 member 9

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-117549 Ibrolipim Activator 99.48% Phase 2

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-11032 SM-350300 / Unkown
HY-RS15412 UCP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20349 Ucp3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26858 Ucp3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ucp3 NCBI NCBI:7352