GPRC6A - G protein-coupled receptor class C group 6 member A Gene

Also Known as GPCR; bA86F4.3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 222545

About GPRC6A

Cytogenetic location: 6q22.1 Genomic coordinates (GRCh38): 6:116,792,085-116,829,240 (from NCBI)

This gene has 3 transcripts (splice variants), 218 orthologues and 4 paralogues. Low expression observed in reference dataset.

Summary

Members of family C of the G protein-coupled receptor (GPCR) superfamily, such as GPRC6A, are characterized by an evolutionarily conserved amino acid-sensing motif linked to an intramembranous 7-transmembrane loop region. Several members of GPCR family C, including GPRC6A, also have a long N-terminal domain (summary by Pi et al., 2005 [PubMed 16199532]).[supplied by OMIM, Nov 2010]

GPRC6A Products (3)

mRNA Protein Name
NM_001286354.1 NP_001273283.1 G-protein coupled receptor family C group 6 member A isoform 2 precursor
NM_001286355.1 NP_001273284.1 G-protein coupled receptor family C group 6 member A isoform 3 precursor
NM_148963.4 NP_683766.2 G-protein coupled receptor family C group 6 member A isoform 1 precursor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in response to amino acid IDA
IDA: Inferred from direct assay
17478059 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPRC6A Protein Structure

ANF_receptor

ANF_receptor: Receptor family ligand binding region (75 - 479)

NCD3G

NCD3G: Nine Cysteines Domain of family 3 GPCR (519 - 571)

7tm_3

7tm_3: 7 transmembrane sweet-taste receptor of 3 GCPR (603 - 837)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 926 a.a.
Protein Preferred Names Protein Names

G-protein coupled receptor family C group 6 member A

  • G protein-coupled receptor, family C, group 6, member A

Related Diseases

Diseases Alias
Hyperparathyroidism

  • Hyperparathyroidism And Other Disorders Of Parathyroid Gland

  • Parathyroid Hyperfunction

  • Hpth - [Hyperparathyroidism]

  • Parathyroid Gland Hyperfunction

  • Parathyroid Glandular Hyperfunction
Ocular Albinism

  • Albinism, Ocular

  • Oa

  • Xloa

  • Albinism Ocular
Body Mass Index Quantitative Trait Locus 11

  • OBESITY

  • Obesity, Susceptibility To

  • Leanness, Inherited

  • Obesity, Susceptibility To, Bmiq11

  • Obesity, Mild, Early-Onset

  • Obesity, Association With

  • Obesity, Early-Onset, Susceptibility To

  • Obesity, Severe

  • Obesity, Severe, And Type Ii Diabetes

  • Obesity, Late-Onset

  • Obesity , Susceptibility To

  • BMIQ11

  • Obesity Bmiq11

  • Obesity, Early-Onset

  • Simple Obesity Nos

  • Excess Fat

  • Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

  • Adiposis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-114165 DJ-V-159 Agonist 99.94% Unkown
HY-P10413 SHBG(141–161) Agonist 98.78% Unkown
HY-RS05753 GPRC6A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19062 Gprc6a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25552 Gprc6a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris GPRC6A VGNC VGNC:41452
Macaca mulatta GPRC6A VGNC VGNC:72965
Felis catus GPRC6A VGNC VGNC:102433
Rattus norvegicus GPRC6A RGD RGD:735077
Mus musculus GPRC6A MGD MGI:2429498
Others GPRC6A NCBI