Ung - uracil DNA glycosylase Gene

Also Known as UNG1; UNG2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22256

Summary

Enables uracil DNA N-glycosylase activity. Acts upstream of or within isotype switching and somatic hypermutation of immunoglobulin genes. Located in mitochondrion and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; lung; and olfactory epithelium. Human ortholog(s) of this gene implicated in dysgammaglobulinemia and immunodeficiency with hyper IgM type 5. Orthologous to human UNG (uracil DNA glycosylase). [provided by Alliance of Genome Resources, Apr 2022]

Ung Products (2)

mRNA Protein Name
NM_001040691.1 NP_001035781.1 uracil-DNA glycosylase isoform a
NM_011677.2 NP_035807.2 uracil-DNA glycosylase isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables uracil DNA N-glycosylase activity IDA
IDA: Inferred from direct assay
10871356 MGI
enables uracil DNA N-glycosylase activity IMP
IMP: Inferred from mutant phenotype
15494304 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within isotype switching IGI
IGI: Inferred from genetic interaction
17015724 MGI
acts upstream of or within somatic hypermutation of immunoglobulin genes IGI
IGI: Inferred from genetic interaction
15494304 MGI
acts upstream of or within somatic hypermutation of immunoglobulin genes IMP
IMP: Inferred from mutant phenotype
17015724 MGI
acts upstream of or within somatic recombination of immunoglobulin gene segments IGI
IGI: Inferred from genetic interaction
15494304 MGI
acts upstream of or within somatic recombination of immunoglobulin gene segments IMP
IMP: Inferred from mutant phenotype
15494304 MGI
Cellular Component GO Annotation Evidence References Source
located in mitochondrion IDA
IDA: Inferred from direct assay
10871356 MGI
located in nucleus IDA
IDA: Inferred from direct assay
10871356 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

uracil-DNA glycosylase

  • UDG

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-E70217 Uracil DNA Glycosylase (UDG/UNG), heat-sensitive / Unkown
HY-RS15478 UNG Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-112333 SC-68376 Inhibitor / Unkown
HY-RS18026 Ung Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24499 Ung Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ung NCBI NCBI:7374