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SLC29A4 - solute carrier family 29 member 4 Gene

Also Known as ENT4; PMAT

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 222962

About SLC29A4

Cytogenetic location: 7p22.1 Genomic coordinates (GRCh38): 7:5,282,943-5,306,912 (from NCBI)

This gene has 6 transcripts (splice variants), 196 orthologues and 3 paralogues. Biased expression in fat (RPKM 35.4), adrenal (RPKM 3.7) and 4 other tissues.

Summary

This gene encodes a member of the SLC29A/ENT transporter protein family. The encoded membrane protein catalyzes the reuptake of monoamines into presynaptic neurons, thus determining the intensity and duration of monoamine neural signaling. It has been shown to transport several compounds, including serotonin, dopamine, and the neurotoxin 1-methyl-4-phenylpyridinium. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

SLC29A4 Products (3)

mRNA	Protein	Name
NM_001040661.3	NP_001035751.1	equilibrative nucleoside transporter 4 isoform 1
NM_001300847.3	NP_001287776.1	equilibrative nucleoside transporter 4 isoform 2
NM_153247.4	NP_694979.2	equilibrative nucleoside transporter 4 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables efflux transmembrane transporter activity	IDA IDA: Inferred from direct assay	16099839	GOA
enables efflux transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	31842924	GOA
enables monoamine transmembrane transporter activity	IDA IDA: Inferred from direct assay	15448143	GOA
enables monoamine transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	23505051	GOA
enables neurotransmitter transmembrane transporter activity	IDA IDA: Inferred from direct assay	15448143	GOA
enables neurotransmitter transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	23505051	GOA
enables organic acid transmembrane transporter activity	IDA IDA: Inferred from direct assay	26376205	GOA
enables organic cation transmembrane transporter activity	IDA IDA: Inferred from direct assay	16099839	GOA
enables xenobiotic transmembrane transporter activity	IDA IDA: Inferred from direct assay	26376205	GOA
enables xenobiotic transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	31842924	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in adenosine transport	IDA IDA: Inferred from direct assay	16873718	GOA
involved in dopamine transport	IDA IDA: Inferred from direct assay	15448143	GOA
involved in dopamine uptake	IDA IDA: Inferred from direct assay	20858707	GOA
involved in epinephrine transport	IDA IDA: Inferred from direct assay	15448143	GOA
involved in epinephrine uptake	IDA IDA: Inferred from direct assay	20858707	GOA
involved in export across plasma membrane	IMP IMP: Inferred from mutant phenotype	31842924	GOA
involved in histamine transport	IDA IDA: Inferred from direct assay	16099839	GOA
involved in histamine uptake	IDA IDA: Inferred from direct assay	20858707	GOA
involved in histamine uptake	IMP IMP: Inferred from mutant phenotype	23505051	GOA
involved in monoamine transport	IMP IMP: Inferred from mutant phenotype	23505051	GOA
involved in neurotransmitter transport	IDA IDA: Inferred from direct assay	20858707	GOA
involved in norepinephrine transport	IDA IDA: Inferred from direct assay	15448143	GOA
involved in norepinephrine uptake	IDA IDA: Inferred from direct assay	20858707	GOA
involved in organic acid transmembrane transport	IDA IDA: Inferred from direct assay	26376205	GOA
involved in organic cation transport	IDA IDA: Inferred from direct assay	26376205	GOA
involved in serotonin transport	IDA IDA: Inferred from direct assay	15448143	GOA
involved in serotonin uptake	IDA IDA: Inferred from direct assay	20858707	GOA
involved in xenobiotic transport	IDA IDA: Inferred from direct assay	20858707	GOA
involved in xenobiotic transport	IMP IMP: Inferred from mutant phenotype	31842924	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	17018840	GOA
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	26376205	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	20858707	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC29A4 Protein Structure

Nucleoside_tran

0
100
200
300
400
500
530 a.a.

Protein Preferred Names	Protein Names
equilibrative nucleoside transporter 4	plasma membrane monoamine transporter

Related Diseases

Diseases	Alias
Ocular Hyperemia	Hyperemia Eye Hyperemia Of Conjunctiva
Brain Compression	Compression Of Brain

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13156	SLC29A4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SLC29A4	MGD	MGI:2385330
Rattus norvegicus	SLC29A4	RGD	RGD:1310545
Felis catus	SLC29A4	VGNC	VGNC:65298
Canis familiaris	SLC29A4	VGNC	VGNC:46336
Bos taurus	SLC29A4	VGNC	VGNC:34795
Macaca mulatta	SLC29A4	VGNC	VGNC:77562
Others	SLC29A4	NCBI