Was - Wiskott-Aldrich syndrome Gene

Also Known as Wasp

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22376

Summary

Enables identical protein binding activity. Acts upstream of or within several processes, including actin filament polymerization; cellular response to interferon-gamma; and endosomal transport. Located in cell-cell junction; phagocytic vesicle; and vesicle membrane. Is expressed in brain; heart; liver; and spleen. Used to study IgA glomerulonephritis and Wiskott-Aldrich syndrome. Human ortholog(s) of this gene implicated in Wiskott-Aldrich syndrome; X-linked severe congenital neutropenia; and thrombocytopenia. Orthologous to human WAS (WASP actin nucleation promoting factor). [provided by Alliance of Genome Resources, Apr 2022]

Was Products (1)

mRNA Protein Name
NM_009515.2 NP_033541.1 actin nucleation-promoting factor WAS

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IDA
IDA: Inferred from direct assay
12147689 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10967094 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within T cell activation IMP
IMP: Inferred from mutant phenotype
11070165 MGI
acts upstream of or within actin filament polymerization IDA
IDA: Inferred from direct assay
12147689 MGI
acts upstream of or within actin filament-based movement IDA
IDA: Inferred from direct assay
12147689 MGI
acts upstream of or within actin polymerization or depolymerization IDA
IDA: Inferred from direct assay
12147689 MGI
acts upstream of or within cellular response to type II interferon IDA
IDA: Inferred from direct assay
19144319 MGI
acts upstream of or within endosomal transport IDA
IDA: Inferred from direct assay
12147689 MGI
Cellular Component GO Annotation Evidence References Source
located in cell-cell junction IDA
IDA: Inferred from direct assay
23793062 MGI
located in phagocytic vesicle IDA
IDA: Inferred from direct assay
19144319 MGI
located in vesicle membrane IDA
IDA: Inferred from direct assay
12147689 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

actin nucleation-promoting factor WAS

  • Wiskott-Aldrich syndrome homolog

  • wiskott-Aldrich syndrome protein homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15741 WAS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19871 Was Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26370 Was Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Was NCBI NCBI:7454