Wdr1 - WD repeat domain 1 Gene

Also Known as Aip1; rede; D5Wsu185e

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22388

Summary

Predicted to enable actin filament binding activity. Involved in several processes, including Cytoskeleton organization; establishment of planar polarity of follicular epithelium; and platelet formation. Acts upstream of or within positive regulation of actin filament depolymerization; regulation of ventricular cardiac muscle cell membrane repolarization; and sarcomere organization. Located in myelin sheath. Is expressed in several structures, including genitourinary system; heart; pharynx mesenchyme; telencephalon; and trunk mesenchyme. Orthologous to human WDR1 (WD repeat domain 1). [provided by Alliance of Genome Resources, Apr 2022]

Wdr1 Products (1)

mRNA Protein Name
NM_011715.3 NP_035845.1 WD repeat-containing protein 1

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
24840128 MGI
involved in actin filament fragmentation IMP
IMP: Inferred from mutant phenotype
25915128 MGI
involved in cortical cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
17515402 MGI
involved in establishment of planar polarity of follicular epithelium IMP
IMP: Inferred from mutant phenotype
25915128 MGI
involved in neutrophil mediated immunity IMP
IMP: Inferred from mutant phenotype
17515402 MGI
involved in neutrophil migration IMP
IMP: Inferred from mutant phenotype
17515402 MGI
involved in platelet formation IMP
IMP: Inferred from mutant phenotype
17515402 MGI
acts upstream of or within positive regulation of actin filament depolymerization IGI
IGI: Inferred from genetic interaction
24840128 MGI
involved in regulation of cell shape IMP
IMP: Inferred from mutant phenotype
25915128 MGI
acts upstream of or within regulation of ventricular cardiac muscle cell membrane repolarization IMP
IMP: Inferred from mutant phenotype
24840128 MGI
acts upstream of or within sarcomere organization IMP
IMP: Inferred from mutant phenotype
24840128 MGI
Cellular Component GO Annotation Evidence References Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
31171447 MGI
is active in synapse IDA
IDA: Inferred from direct assay
31171447 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

WD repeat-containing protein 1

  • WD40 repeat protein 1

  • actin-interacting protein 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15760 WDR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19974 Wdr1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26477 Wdr1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Wdr1 NCBI NCBI:9948