Rbbp8 - retinoblastoma binding protein 8, endonuclease Gene

Also Known as RIM; CtIP; SAE2; RBBP-8; 9930104E21Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 225182

Summary

Predicted to enable several functions, including DNA binding activity; identical protein binding activity; and single-stranded DNA endodeoxyribonuclease activity. Acts upstream of or within G1/S transition of mitotic cell cycle and blastocyst hatching. Predicted to be located in nucleoplasm. Predicted to be part of transcription repressor complex. Predicted to be active in site of double-strand break. Human ortholog(s) of this gene implicated in Seckel syndrome 2. Orthologous to human RBBP8 (RB binding protein 8, Endonuclease). [provided by Alliance of Genome Resources, Apr 2022]

Rbbp8 Products (2)

mRNA Protein Name
NM_001081223.2 NP_001074692.1 DNA endonuclease RBBP8
NM_001252495.1 NP_001239424.1 DNA endonuclease RBBP8

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within G1/S transition of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
15831459 MGI
acts upstream of or within blastocyst hatching IMP
IMP: Inferred from mutant phenotype
15831459 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA endonuclease RBBP8

  • ctBP-interacting protein

  • retinoblastoma-binding protein 8

  • sporulation in the absence of SPO11 protein 2 homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11720 RBBP8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20478 Rbbp8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26986 Rbbp8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rbbp8 NCBI NCBI:5932