Xrcc1 - X-ray repair complementing defective repair in Chinese hamster cells 1 Gene

Also Known as Xrcc-1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 22594

Summary

Contributes to 3' overhang single-stranded DNA endodeoxyribonuclease activity. Involved in several processes, including DNA metabolic process; negative regulation of protein ADP-ribosylation; and regulation of response to DNA damage stimulus. Acts upstream of or within DNA repair and hippocampus development. Located in chromosome, telomeric region. Part of ERCC4-ERCC1 complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive spinocerebellar ataxia 26; carcinoma (multiple); hematologic Cancer (multiple); hepatitis A; and reproductive organ Cancer (multiple). Orthologous to human XRCC1 (X-ray repair cross complementing 1). [provided by Alliance of Genome Resources, Apr 2022]

Xrcc1 Products (4)

mRNA	Protein	Name
NM_001360168.1	NP_001347097.1	DNA repair protein XRCC1 isoform 2
NM_001360169.1	NP_001347098.1	DNA repair protein XRCC1 isoform 3
NM_001360170.1	NP_001347099.1	DNA repair protein XRCC1 isoform 4
NM_009532.5	NP_033558.3	DNA repair protein XRCC1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
contributes to 3' overhang single-stranded DNA endodeoxyribonuclease activity	IMP IMP: Inferred from mutant phenotype	14690602	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within DNA repair	IMP IMP: Inferred from mutant phenotype	19633665	MGI
involved in cerebellum morphogenesis	IMP IMP: Inferred from mutant phenotype	28002403	MGI
involved in double-strand break repair via nonhomologous end joining	IMP IMP: Inferred from mutant phenotype	14690602	MGI
acts upstream of or within hippocampus development	IMP IMP: Inferred from mutant phenotype	19633665	MGI
involved in negative regulation of protection from non-homologous end joining at telomere	IMP IMP: Inferred from mutant phenotype	14690602	MGI
involved in negative regulation of protein ADP-ribosylation	IMP IMP: Inferred from mutant phenotype	28002403	MGI
involved in positive regulation of single strand break repair	IGI IGI: Inferred from genetic interaction	28002403	MGI
involved in telomeric DNA-containing double minutes formation	IMP IMP: Inferred from mutant phenotype	14690602	MGI
involved in voluntary musculoskeletal movement	IGI IGI: Inferred from genetic interaction	28002403	MGI
involved in voluntary musculoskeletal movement	IMP IMP: Inferred from mutant phenotype	28002403	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of ERCC4-ERCC1 complex	IDA IDA: Inferred from direct assay	14690602	MGI
located in chromosome, telomeric region	IDA IDA: Inferred from direct assay	14690602	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
DNA repair protein XRCC1	X-ray repair cross-complementing protein 1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-171789	PARG-IN-7	Inhibitor	/	Unkown
HY-RS15896	XRCC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20130	Xrcc1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26634	Xrcc1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Xrcc1	NCBI	NCBI:7515