Ywhaz - tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide Gene

Also Known as 14-3-3zeta; 1110013I11Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 22631

Summary

Enables protein domain specific binding activity. Involved in several processes, including respiratory system process; synaptic target recognition; and tube morphogenesis. Acts upstream of or within ERK1 and ERK2 cascade; protein targeting; and regulation of cell death. Located in hippocampal mossy fiber to CA3 synapse and nucleus. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and hemolymphoid system gland. Used to study schizophrenia. Orthologous to human YWHAZ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta). [provided by Alliance of Genome Resources, Apr 2022]

Ywhaz Products (5)

mRNA	Protein	Name
NM_001253805.1	NP_001240734.1	14-3-3 protein zeta/delta isoform 1
NM_001253806.1	NP_001240735.1	14-3-3 protein zeta/delta isoform 1
NM_001253807.1	NP_001240736.1	14-3-3 protein zeta/delta isoform 2
NM_001356569.1	NP_001343498.1	14-3-3 protein zeta/delta isoform 1
NM_011740.3	NP_035870.1	14-3-3 protein zeta/delta isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11124266	MGI
enables protein domain specific binding	IDA IDA: Inferred from direct assay	12176995	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	29118970	MGI
acts upstream of or within angiogenesis	IGI IGI: Inferred from genetic interaction	29118970	MGI
involved in angiogenesis	IMP IMP: Inferred from mutant phenotype	29118970	MGI
involved in lung development	IMP IMP: Inferred from mutant phenotype	29118970	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	21621563	MGI
acts upstream of or within protein targeting	IDA IDA: Inferred from direct assay	12446771	MGI
acts upstream of or within regulation of programmed cell death	IGI IGI: Inferred from genetic interaction	19451227	MGI
involved in respiratory system process	IMP IMP: Inferred from mutant phenotype	29118970	MGI
involved in synaptic target recognition	IDA IDA: Inferred from direct assay	22124272	MGI
involved in synaptic target recognition	IMP IMP: Inferred from mutant phenotype	22124272	MGI
acts upstream of or within tube formation	IGI IGI: Inferred from genetic interaction	29118970	MGI
involved in tube formation	IMP IMP: Inferred from mutant phenotype	29118970	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in hippocampal mossy fiber to CA3 synapse	IDA IDA: Inferred from direct assay	22124272	MGI
is active in hippocampal mossy fiber to CA3 synapse	IMP IMP: Inferred from mutant phenotype	22124272	MGI
located in nucleus	IDA IDA: Inferred from direct assay	15615787	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
14-3-3 protein zeta/delta	14-3-3 zeta KCIP-1 SEZ-2 protein kinase C inhibitor protein 1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15945	YWHAZ Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18690	Ywhaz Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25176	Ywhaz Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ywhaz	NCBI	NCBI:7534