Ndufs2 - NADH:ubiquinone oxidoreductase core subunit S2 Gene

Also Known as CI-49kD

Species: Mus musculus

Gene Type: protein coding
Gene ID: 226646

Summary

Enables NADH dehydrogenase (ubiquinone) activity and oxygen sensor activity. Involved in several processes, including cellular response to oxygen levels; gliogenesis; and mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Leigh disease; hypertrophic cardiomyopathy; inherited metabolic disorder; multiple sclerosis; and nuclear type mitochondrial complex I deficiency 6. Orthologous to human NDUFS2 (NADH:ubiquinone oxidoreductase core subunit S2). [provided by Alliance of Genome Resources, Apr 2022]

Ndufs2 Products (2)

mRNA Protein Name
NM_153064.5 NP_694704.1 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial precursor
NM_153064.5 NP_694704.1 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables NADH dehydrogenase (ubiquinone) activity IMP
IMP: Inferred from mutant phenotype
26437605 MGI
enables oxygen sensor activity IMP
IMP: Inferred from mutant phenotype
26437605 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
32279995 MGI
Biological Process GO Annotation Evidence References Source
involved in cellular response to oxygen levels IMP
IMP: Inferred from mutant phenotype
26437605 MGI
involved in gliogenesis IMP
IMP: Inferred from mutant phenotype
31297047 MGI
involved in mitochondrial respiratory chain complex I assembly IMP
IMP: Inferred from mutant phenotype
26437605 MGI
involved in neural precursor cell proliferation IMP
IMP: Inferred from mutant phenotype
31297047 MGI
involved in neurogenesis IMP
IMP: Inferred from mutant phenotype
31297047 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

  • NADH dehydrogenase (ubiquinone) Fe-S protein 2

  • NADH-coenzyme Q reductase

  • NADH-ubiquinone oxidoreductase 49 kDa subunit

  • complex I-49kD

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09158 NDUFS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21898 Ndufs2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ndufs2 NCBI NCBI:4720