Gsn - gelsolin Gene

Also Known as ADF

Species: Mus musculus

Gene Type: protein coding

Gene ID: 227753

Summary

Enables phosphatidylinositol 3-kinase catalytic subunit binding activity. Involved in several processes, including actin filament capping; actin polymerization or depolymerization; and positive regulation of protein processing in phagocytic vesicle. Acts upstream of or within cellular response to interferon-gamma and vesicle-mediated transport. Located in lamellipodium and phagocytic vesicle. Colocalizes with focal adhesion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in Finnish type amyloidosis. Orthologous to human GSN (gelsolin). [provided by Alliance of Genome Resources, Apr 2022]

Gsn Products (7)

mRNA	Protein	Name
NM_001206367.1	NP_001193296.1	gelsolin isoform 2
NM_001206368.1	NP_001193297.1	gelsolin isoform 2
NM_001206369.1	NP_001193298.1	gelsolin isoform 2
NM_001362945.1	NP_001349874.1	gelsolin isoform 3
NM_001362947.1	NP_001349876.1	gelsolin isoform 3
NM_001362948.1	NP_001349877.1	gelsolin isoform 2
NM_146120.4	NP_666232.2	gelsolin isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables phosphatidylinositol 3-kinase catalytic subunit binding	IPI IPI: Inferred from physical interaction	30568254	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	23055941	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	30568254	MGI
involved in actin filament capping	IDA IDA: Inferred from direct assay	23325791	MGI
involved in actin filament depolymerization	IMP IMP: Inferred from mutant phenotype	30568254	MGI
involved in actin filament polymerization	IDA IDA: Inferred from direct assay	23325791	MGI
involved in actin filament severing	IMP IMP: Inferred from mutant phenotype	23325791	MGI
involved in cardiac muscle cell contraction	IMP IMP: Inferred from mutant phenotype	30568254	MGI
acts upstream of or within cellular response to type II interferon	IDA IDA: Inferred from direct assay	19144319	MGI
involved in phagocytosis, engulfment	IMP IMP: Inferred from mutant phenotype	23325791	MGI
involved in positive regulation of protein processing in phagocytic vesicle	IMP IMP: Inferred from mutant phenotype	23325791	MGI
involved in relaxation of cardiac muscle	IMP IMP: Inferred from mutant phenotype	30568254	MGI
involved in response to muscle stretch	IMP IMP: Inferred from mutant phenotype	30568254	MGI
acts upstream of or within vesicle-mediated transport	IMP IMP: Inferred from mutant phenotype	11514591	MGI

Cellular Component GO Annotation	Evidence	References	Source
colocalizes with focal adhesion	IDA IDA: Inferred from direct assay	23325791	MGI
located in lamellipodium	IDA IDA: Inferred from direct assay	15294161	MGI
located in phagocytic vesicle	IDA IDA: Inferred from direct assay	19144319	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
gelsolin	actin-depolymerizing factor brevin

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-133870	Itaconate-alkyne		98.01%	Unkown
HY-RS18449	Gsn Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS05867	GSN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24931	Gsn Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gsn	NCBI	NCBI:2934