CLCA4 - chloride channel accessory 4 Gene
Also Known as CaCC; CaCC2
Species: Homo sapiens
About CLCA4
This gene has 2 transcripts (splice variants), 130 orthologues, 2 paralogues and is associated with 1 phenotype. Biased expression in colon (RPKM 204.3), esophagus (RPKM 195.4) and 1 other tissue.
Summary
The protein encoded by this gene belongs to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. Alternative splicing results in multiple transcript variants, only one of which is thought to be protein coding. [provided by RefSeq, Dec 2008]
CLCA4 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_012128.4 | NP_036260.2 | calcium-activated chloride channel regulator 4 precursor |
CLCA4 Protein Structure
CLCA: Calcium-activated chloride channel N terminal (1 - 261)
VWA_2: von Willebrand factor type A domain (307 - 467)
(487 - 663)
- 0
- 200
- 400
- 600
- 800
- 919 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
calcium-activated chloride channel regulator 4 |
|
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Cystic Fibrosis |
|
|
| Leopard Syndrome 2 |
|
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| Colon Mucinous Adenocarcinoma |
|
|
| Noonan Syndrome 5 |
|
|
| Cecum Adenocarcinoma |
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Felis catus | CLCA4 | VGNC | VGNC:60920 |
| Canis familiaris | CLCA4 | VGNC | VGNC:39298 |
| Bos taurus | CLCA4 | VGNC | VGNC:54909 |
| Macaca mulatta | CLCA4 | VGNC | VGNC:99868 |
| Rattus norvegicus | CLCA4 | RGD | RGD:1303234 |
| Others | CLCA4 | NCBI |