HSPA4L - heat shock protein family A (Hsp70) member 4 like Gene

Also Known as APG1; APG-1; HSPH3; Osp94

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 22824

About HSPA4L

Cytogenetic location: 4q28.1 Genomic coordinates (GRCh38): 4:127,781,796-127,840,733 (from NCBI)

This gene has 5 transcripts (splice variants), 217 orthologues and 13 paralogues. Biased expression in testis (RPKM 41.4), esophagus (RPKM 5.8) and 4 other tissues.

Summary

The protein encoded by this gene is heat shock inducible and may act as a chaperone. The encoded protein can protect the heat-shocked cell against the harmful effects of aggregated proteins. This gene is highly expressed in leukemia cells and may be a good target for therapeutic intervention. Several transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

HSPA4L Products (4)

mRNA Protein Name
NM_001317381.2 NP_001304310.1 heat shock 70 kDa protein 4L isoform 2
NM_001317382.2 NP_001304311.1 heat shock 70 kDa protein 4L isoform 3
NM_001317383.2 NP_001304312.1 heat shock 70 kDa protein 4L isoform 4
NM_014278.4 NP_055093.2 heat shock 70 kDa protein 4L isoform 1

HSPA4L Protein Structure

HSP70

HSP70: Hsp70 protein (3 - 579)

HSP70

HSP70: Hsp70 protein (593 - 693)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 839 a.a.
Protein Preferred Names Protein Names

heat shock 70 kDa protein 4L

  • HSPA4-like protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06431 HSPA4L Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21867 Hspa4l Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus HSPA4L MGD MGI:107422
Felis catus HSPA4L VGNC VGNC:78511
Bos taurus HSPA4L VGNC VGNC:53906
Macaca mulatta HSPA4L VGNC VGNC:100236
Rattus norvegicus HSPA4L RGD RGD:1306528
Canis familiaris HSPA4L VGNC VGNC:54806
Others HSPA4L NCBI