PPM1E - protein phosphatase, Mg2+/Mn2+ dependent 1E Gene

Also Known as POPX1; PP2CH; caMKN; CAMKPN; CaMKP-N

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 22843

About PPM1E

Cytogenetic location: 17q22 Genomic coordinates (GRCh38): 17:58,755,854-58,985,179 (from NCBI)

This gene has 1 transcript (splice variant), 207 orthologues and 16 paralogues. Biased expression in brain (RPKM 6.5), testis (RPKM 3.8) and 3 other tissues.

Summary

This gene encodes a member of the PPM family of serine/threonine-protein phosphatases. The encoded protein is localized to the nucleus and dephosphorylates and inactivates multiple substrates including serine/threonine-protein kinase PAK 1, 5'-AMP-activated protein kinase (AMPK) and the multifunctional calcium/calmodulin-dependent protein kinases. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]

PPM1E Products (1)

mRNA Protein Name
NM_014906.5 NP_055721.3 protein phosphatase 1E

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11864573 GOA
enables protein serine/threonine phosphatase activity IDA
IDA: Inferred from direct assay
20801214 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
27793001 GOA
involved in cellular response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
20801214 GOA
involved in negative regulation of protein kinase activity IDA
IDA: Inferred from direct assay
11864573 GOA
involved in peptidyl-threonine dephosphorylation IDA
IDA: Inferred from direct assay
20801214 GOA
involved in positive regulation of stress fiber assembly IDA
IDA: Inferred from direct assay
11864573 GOA
Cellular Component GO Annotation Evidence References Source
part of protein-containing complex IDA
IDA: Inferred from direct assay
11864573 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPM1E Protein Structure

PP2C

PP2C: Protein phosphatase 2C (233 - 481)

  • 0
  • 200
  • 400
  • 600
  • 755 a.a.
Protein Preferred Names Protein Names

protein phosphatase 1E

  • ca(2+)/calmodulin-dependent protein kinase phosphatase N

PPM1E Antibodies

Cat. No. Product Name Application Reactivity
HY-P87013 PPM1E Antibody (YA6706) WB Human

Related Diseases

Diseases Alias
Mulibrey Nanism

  • MUL

  • Muscle-Liver-Brain-Eye Nanism

  • Pericardial Constriction And Growth Failure

  • Perheentupa Syndrome

  • Mulibrey Growth Disorder

  • Mulibrey Nanism Syndrome

  • Pericardial Constriction With Growth Failure

  • Nanism Mulibrey
Osteoblastoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10963 PPM1E Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21029 Ppm1e Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27546 Ppm1e Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PPM1E VGNC VGNC:33211
Rattus norvegicus PPM1E RGD RGD:735028
Felis catus PPM1E VGNC VGNC:99323
Macaca mulatta PPM1E VGNC VGNC:76073
Canis familiaris PPM1E VGNC VGNC:44865
Mus musculus PPM1E MGD MGI:2444096
Others PPM1E NCBI