CARD8 - caspase recruitment domain family member 8 Gene

Also Known as NDPP; DACAR; DAKAR; NDPP1; TUCAN; CARDINAL

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 22900

About CARD8

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:48,179,825-48,255,946 (from NCBI)

This gene has 31 transcripts (splice variants), 96 orthologues and is associated with 1 phenotype. Broad expression in spleen (RPKM 13.6), lymph node (RPKM 11.5) and 24 other tissues.

Summary

The protein encoded by this gene belongs to the Caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and Apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]

CARD8 Products (17)

mRNA Protein Name
NM_001184900.3 NP_001171829.1 caspase recruitment domain-containing protein 8 isoform a
NM_001184901.1 NP_001171830.1 caspase recruitment domain-containing protein 8 isoform b
NM_001184902.2 NP_001171831.1 caspase recruitment domain-containing protein 8 isoform c
NM_001184903.1 NP_001171832.1 caspase recruitment domain-containing protein 8 isoform c
NM_001184904.2 NP_001171833.1 caspase recruitment domain-containing protein 8 isoform d
NM_001351782.2 NP_001338711.1 caspase recruitment domain-containing protein 8 isoform a
NM_001351783.2 NP_001338712.1 caspase recruitment domain-containing protein 8 isoform b
NM_001351784.2 NP_001338713.1 caspase recruitment domain-containing protein 8 isoform e
NM_001351786.2 NP_001338715.1 caspase recruitment domain-containing protein 8 isoform f
NM_001351787.2 NP_001338716.1 caspase recruitment domain-containing protein 8 isoform g
NM_001351788.2 NP_001338717.1 caspase recruitment domain-containing protein 8 isoform h
NM_001351789.2 NP_001338718.1 caspase recruitment domain-containing protein 8 isoform h
NM_001351790.2 NP_001338719.1 caspase recruitment domain-containing protein 8 isoform i
NM_001351791.2 NP_001338720.1 caspase recruitment domain-containing protein 8 isoform j
NM_001351792.2 NP_001338721.1 caspase recruitment domain-containing protein 8 isoform j
NM_001365950.1 NP_001352879.1 caspase recruitment domain-containing protein 8 isoform k
NM_014959.5 NP_055774.2 caspase recruitment domain-containing protein 8 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables CARD domain binding IPI
IPI: Inferred from physical interaction
11821383 GOA
enables NACHT domain binding IPI
IPI: Inferred from physical interaction
15030775 GOA
enables cysteine-type endopeptidase activator activity IDA
IDA: Inferred from direct assay
15030775 GOA
enables endopeptidase activity IDA
IDA: Inferred from direct assay
22087307 GOA
enables molecular condensate scaffold activity IDA
IDA: Inferred from direct assay
33053349 GOA
enables pattern recognition receptor activity IDA
IDA: Inferred from direct assay
33542150 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11551959 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
15030775 GOA
Biological Process GO Annotation Evidence References Source
involved in CARD8 inflammasome complex assembly IDA
IDA: Inferred from direct assay
31525884 GOA
involved in antiviral innate immune response IDA
IDA: Inferred from direct assay
33542150 GOA
involved in defense response to virus IDA
IDA: Inferred from direct assay
33542150 GOA
involved in inhibition of cysteine-type endopeptidase activity IDA
IDA: Inferred from direct assay
11821383 GOA
involved in negative regulation of NF-kappaB transcription factor activity IMP
IMP: Inferred from mutant phenotype
11821383 GOA
involved in negative regulation of NLRP3 inflammasome complex assembly IDA
IDA: Inferred from direct assay
24517500 GOA
involved in negative regulation of canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
11551959 GOA
involved in negative regulation of interleukin-1 beta production IDA
IDA: Inferred from direct assay
11821383 GOA
involved in negative regulation of lipopolysaccharide-mediated signaling pathway IDA
IDA: Inferred from direct assay
11821383 GOA
involved in negative regulation of tumor necrosis factor-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
11821383 GOA
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
IDA: Inferred from direct assay
11821383 GOA
involved in positive regulation of interleukin-1 beta production IDA
IDA: Inferred from direct assay
15030775 GOA
involved in protein homooligomerization IDA
IDA: Inferred from direct assay
33420028 GOA
involved in pyroptotic inflammatory response IDA
IDA: Inferred from direct assay
32840892 GOA
involved in self proteolysis IDA
IDA: Inferred from direct assay
33542150 GOA
Cellular Component GO Annotation Evidence References Source
part of CARD8 inflammasome complex IDA
IDA: Inferred from direct assay
15030775 GOA
part of NLRP3 inflammasome complex IDA
IDA: Inferred from direct assay
15030775 GOA
part of canonical inflammasome complex IDA
IDA: Inferred from direct assay
34019797 GOA
is active in cytoplasm IDA
IDA: Inferred from direct assay
24517500 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
15030775 GOA
located in nucleus IDA
IDA: Inferred from direct assay
11551959 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
11821383 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CARD8 Protein Structure

FIIND

FIIND: Function to find (182 - 437)

CARD

CARD: Caspase recruitment domain (452 - 534)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 537 a.a.
Protein Preferred Names Protein Names

caspase recruitment domain-containing protein 8

  • CARD inhibitor of NF-kappaB-activating ligands

Related Diseases

Diseases Alias
Inflammatory Bowel Disease 30

  • Inflammatory Bowel Disease 30

  • IBD30
Pharyngitis

  • Acute Pharyngitis

  • Chronic Pharyngitis

  • Acute Sore Throat

  • Chronic Sore Throat

  • Persistent Sore Throat

  • Pharyngeal Diseases

  • Chronic Pharyn/Nasopharyngitis

  • Chronic Pharyngitis And Nasopharyngitis

  • Inflamed Throat

  • Pharyngeal Disease

  • Pharyngeal Disorder

  • Pharyngitis - Acute

  • Sore Throat - Chronic

  • Acute Pharyngitis Nos

  • Acute Sore Throat Nos

  • Acute Throat Inflammation

  • Infective Pharyngitis

  • Infection Of Pharynx

  • Acute Infective Pharyngitis

  • Acute Infective Pharyngitis Nos

  • Acute Pharyngeal Inflammation

  • Inflammation Of The Throat

  • Throat Inflammation

  • Throat Infection

  • Putrid Pharyngitis

  • Pharyngeal Inflammation

  • Pharyngitis Nos

  • Chronic Throat Pain

  • Throat Catarrh
Arteriosclerosis Obliterans
Inflammatory Bowel Disease

  • Inflammatory Bowel Diseases

  • Bowel Disease, Inflammatory
Rheumatoid Arthritis

  • RA

  • Arthritis, Rheumatoid

  • Rheumatoid Arthritis, Susceptibility To

  • Arthritis Or Polyarthritis, Rheumatic

  • Atrophic Arthritis

  • Rheumatism Arthritis

  • Rheumatoid Polyarthritis
Cervical Adenitis

  • Cervical Lymphadenitis
Arthritis

  • Inflammatory Joint Disease

  • Inflammatory Disorder Of Joint
Anthracosis

  • Black Lung

  • Coal Workers' Pneumoconiosis

  • Melanoedema

  • Black Lung Disease

  • Pneumoconiosis

  • Coal Miner'S Pneumoconiosis

  • Coal Workers' Lung

  • Coal Worker'S Pneumoconiosis

  • Coal Workers Pneumoconiosis

  • Coal Miners' Lung

  • Coal Miners' Pneumoconiosis

  • Coal Pneumoconiosis

  • Colliers' Anthracosis

  • Colliers' Lung

  • Lung Melanosis

  • Miners' Asthma

  • Miners' Lung

  • Pneumomelanosis

  • Cwp - [Coalworkers Pneumoconiosis]

  • Fibrosis Of Lung With Anthracosilicosis

  • Lung Fibrosis With Anthracosis

  • Miners' Pneumoconiosis

  • Carbon Lung

  • Coalworker Lung

  • Collier'S Asthma

  • Anthracosilicosis

  • Lung Anthracosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-183739 CQ31 / Unkown
HY-185207 CQ80 Inducer / Unkown
HY-RS01922 CARD8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CARD8 VGNC VGNC:60368
Rattus norvegicus CARD8 RGD RGD:1593294
Others CARD8 NCBI