Pias3 - protein inhibitor of activated STAT 3 Gene

Also Known as Pias3l

Species: Mus musculus

Gene Type: protein coding
Gene ID: 229615

Summary

Enables SUMO transferase activity. Acts upstream of or within several processes, including TNFSF11-mediated signaling pathway; negative regulation of macromolecule metabolic process; and negative regulation of osteoclast differentiation. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; early conceptus; eye; genitourinary system; and maxillary process. Orthologous to human PIAS3 (protein inhibitor of activated STAT 3). [provided by Alliance of Genome Resources, Apr 2022]

Pias3 Products (3)

mRNA Protein Name
NM_001165949.1 NP_001159421.1 E3 SUMO-protein ligase PIAS3 isoform 3
NM_018812.2 NP_061282.2 E3 SUMO-protein ligase PIAS3 isoform 2
NM_146135.2 NP_666247.1 E3 SUMO-protein ligase PIAS3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables SUMO transferase activity IDA
IDA: Inferred from direct assay
15767674 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11060035 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
17442941 MGI
acts upstream of or within negative regulation of gene expression IDA
IDA: Inferred from direct assay
17442941 MGI
acts upstream of or within negative regulation of osteoclast differentiation IDA
IDA: Inferred from direct assay
17442941 MGI
acts upstream of or within negative regulation of osteoclast differentiation IMP
IMP: Inferred from mutant phenotype
17442941 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
17442941 MGI
acts upstream of or within protein sumoylation IDA
IDA: Inferred from direct assay
15767674 MGI
acts upstream of or within regulation of tumor necrosis factor-mediated signaling pathway IDA
IDA: Inferred from direct assay
17442941 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
21812053 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
34459572 MGI
located in nucleus IDA
IDA: Inferred from direct assay
14596924 MGI
is active in postsynaptic cytosol IDA
IDA: Inferred from direct assay
34459572 MGI
is active in presynaptic cytosol IDA
IDA: Inferred from direct assay
34459572 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 SUMO-protein ligase PIAS3

  • E3 SUMO-protein transferase PIAS3

  • protein inhibitor of activated STAT protein 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10475 PIAS3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21688 Pias3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28206 Pias3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pias3 NCBI NCBI:10401