Hcrtr1 - hypocretin (orexin) receptor 1 Gene

Also Known as Ox1r; ox1-R; ox-1-R

Species: Mus musculus

Gene Type: protein coding
Gene ID: 230777

About Hcrtr1

Chromosome 4: 130,024,010-130,033,152 reverse strand.GRCm39:CM000997.3

This gene has 4 transcripts (splice variants), 94 orthologues, 16 paralogues and is associated with 4 phenotypes. Biased expression in bladder adult (RPKM 6.3), stomach adult (RPKM 2.7) and 12 other tissues.

Summary

Predicted to enable orexin receptor activity and peptide hormone binding activity. Acts upstream of or within positive regulation of ERK1 and ERK2 cascade. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including brain; genitourinary system; gut; immune system; and liver and biliary system. Orthologous to human HCRTR1 (hypocretin receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Hcrtr1 Products (4)

mRNA Protein Name
NM_001305392.1 NP_001292321.1 orexin/Hypocretin receptor type 1 isoform 2
NM_001163027.1 NP_001156499.1 orexin/Hypocretin receptor type 1 isoform 1
NM_001357258.1 NP_001344187.1 orexin/Hypocretin receptor type 1 isoform 2
NM_198959.2 NP_945197.2 orexin/Hypocretin receptor type 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
22028875 MGI
Biological Process GO Annotation Evidence Verweise Source
acts upstream of or within positive regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
22028875 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Hcrtr1 Protein Structure

7tmA_OXR

7tmA_OXR: cd15208 (46 - 368)

7tmA_OXR

7tmA_OXR: cd15208 (47 - 73)

7tmA_OXR

7tmA_OXR: cd15208 (80 - 106)

7tmA_OXR

7tmA_OXR: cd15208 (118 - 148)

7tmA_OXR

7tmA_OXR: cd15208 (159 - 180)

7tmA_OXR

7tmA_OXR: cd15208 (211 - 240)

7tmA_OXR

7tmA_OXR: cd15208 (290 - 320)

7tmA_OXR

7tmA_OXR: cd15208 (336 - 361)

  • 0
  • 100
  • 200
  • 300
  • 416 a.a.
Protein Preferred Names Protein Names

orexin/Hypocretin receptor type 1

orexin receptor type 1

  • hypocretin receptor type 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS06051 HCRTR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06052 Hcrtr1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06053 Hcrtr1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hcrtr1 NCBI NCBI:3061