USP24 - ubiquitin specific peptidase 24 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23358

About USP24

Cytogenetic location: 1p32.3 Genomic coordinates (GRCh38): 1:55,066,359-55,215,364 (from NCBI)

This gene has 7 transcripts (splice variants), 164 orthologues and 71 paralogues. Ubiquitous expression in bone marrow (RPKM 9.9), lymph node (RPKM 9.7) and 25 other tissues.

Summary

Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating Enzymes. USP24 belongs to a large family of cysteine proteases that function as deubiquitinating Enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Mar 2008]

USP24 Products (1)

mRNA	Protein	Name
NM_015306.3	NP_056121.2	ubiquitin carboxyl-terminal hydrolase 24

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

USP24 Protein Structure

UCH

0
500
1000
1500
2000
2500
2620 a.a.

Protein Preferred Names	Protein Names
ubiquitin carboxyl-terminal hydrolase 24	deubiquitinating enzyme 24

USP24 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P87132	USP24 Antibody (YA6825)	WB, ICC/IF, IHC-P	Human, Mouse

Related Diseases

Diseases	Alias
Non-Syndromic X-Linked Intellectual Disability 99	Mrx99 X-Linked Mental Retardation 99
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Fanconi Anemia, Complementation Group A	Fanconi Anemia Fanconi Pancytopenia Fanconi Anemia Complementation Group A FANCA Fa Fanconi Panmyelopathy Fanconi'S Anemia Fanconi Anaemia Fanconi'S Anaemia Fanconi Hypoplastic Anemia Estren-Dameshek Variant Of Fanconi Anemia Estren-Dameshek Variant Of Fanconi Pancytopenia Fanconi Anemia Estren-Dameshek Variant Fanconis Anemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-111408	EOAI3402143	Inhibitor	98.11%	Unkown
HY-176557	NCI677397		/	Unkown
HY-RS15534	USP24 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18555	Usp24 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25037	Usp24 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	USP24	VGNC	VGNC:78743
Rattus norvegicus	USP24	RGD	RGD:1306799
Felis catus	USP24	VGNC	VGNC:66874
Mus musculus	USP24	MGD	MGI:1919936
Bos taurus	USP24	VGNC	VGNC:36717
Canis familiaris	USP24	VGNC	VGNC:48183