Spg7 - SPG7, paraplegin matrix AAA peptidase subunit Gene

Also Known as PGN; Cmar

Species: Mus musculus

Gene Type: protein coding
Gene ID: 234847

Summary

Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and peptidase activity. Acts upstream of or within anterograde axonal transport and mitochondrion organization. Located in mitochondrial inner membrane. Part of m-AAA complex. Is expressed in central nervous system; olfactory epithelium; and retina nuclear layer. Used to study hereditary spastic paraplegia 7. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 7. Orthologous to human SPG7 (SPG7 matrix AAA peptidase subunit, paraplegin). [provided by Alliance of Genome Resources, Apr 2022]

Spg7 Products (2)

mRNA Protein Name
NM_001364435.1 NP_001351364.1 paraplegin isoform 2 precursor
NM_153176.5 NP_694816.3 paraplegin isoform 1 preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19656850 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within anterograde axonal transport IMP
IMP: Inferred from mutant phenotype
14722615 MGI
acts upstream of or within mitochondrion organization IMP
IMP: Inferred from mutant phenotype
14722615 MGI
Cellular Component GO Annotation Evidence References Source
part of m-AAA complex IDA
IDA: Inferred from direct assay
19656850 MGI
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
19656850 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
14722615 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

paraplegin

  • cell matrix adhesion regulator

  • spastic paraplegia 7 homolog

  • spastic paraplegia 7 protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13663 SPG7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21436 Spg7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27954 Spg7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Spg7 NCBI NCBI:6687