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ZMYND8 - zinc finger MYND-type containing 8 Gene

Also Known as RACK7; PRKCBP1; PRO2893

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23613

About ZMYND8

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:47,209,214-47,356,699 (from NCBI)

This gene has 21 transcripts (splice variants), 281 orthologues and 5 paralogues. Ubiquitous expression in adrenal (RPKM 6.9), testis (RPKM 4.9) and 25 other tissues.

Summary

The protein encoded by this gene is a receptor for activated C-kinase (RACK) protein. The encoded protein has been shown to bind in vitro to activated protein kinase C beta I. In addition, this protein is a cutaneous T-cell lymphoma-associated antigen. Finally, the protein contains a bromodomain and two zinc fingers, and is thought to be a transcriptional regulator. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

ZMYND8 Products (20)

mRNA	Protein	Name
NM_001281769.2	NP_001268698.1	protein kinase C-binding protein 1 isoform d
NM_001281771.3	NP_001268700.1	protein kinase C-binding protein 1 isoform e
NM_001281772.3	NP_001268701.1	protein kinase C-binding protein 1 isoform f
NM_001281773.3	NP_001268702.1	protein kinase C-binding protein 1 isoform g
NM_001281774.3	NP_001268703.1	protein kinase C-binding protein 1 isoform h
NM_001281775.3	NP_001268704.1	protein kinase C-binding protein 1 isoform i
NM_001281776.3	NP_001268705.1	protein kinase C-binding protein 1 isoform j
NM_001281777.3	NP_001268706.1	protein kinase C-binding protein 1 isoform k
NM_001281778.3	NP_001268707.1	protein kinase C-binding protein 1 isoform l
NM_001281779.3	NP_001268708.1	protein kinase C-binding protein 1 isoform m
NM_001281780.3	NP_001268709.1	protein kinase C-binding protein 1 isoform n
NM_001281781.3	NP_001268710.1	protein kinase C-binding protein 1 isoform o
NM_001281782.3	NP_001268711.1	protein kinase C-binding protein 1 isoform p
NM_001281783.3	NP_001268712.1	protein kinase C-binding protein 1 isoform q
NM_001281784.3	NP_001268713.1	protein kinase C-binding protein 1 isoform r
NM_001363714.1	NP_001350643.1	protein kinase C-binding protein 1 isoform s
NM_001363741.2	NP_001350670.1	protein kinase C-binding protein 1 isoform t
NM_012408.6	NP_036540.3	protein kinase C-binding protein 1 isoform b
NM_183047.4	NP_898868.1	protein kinase C-binding protein 1 isoform a
NM_183048.4	NP_898869.1	protein kinase C-binding protein 1 isoform c

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables lysine-acetylated histone binding	IDA IDA: Inferred from direct assay	27477906	GOA
enables methylated histone binding	IDA IDA: Inferred from direct assay	27477906	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15095401	GOA
enables protein domain specific binding	IDA IDA: Inferred from direct assay	28966017	GOA
enables transcription corepressor activity	IMP IMP: Inferred from mutant phenotype	27477906	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	28966017	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in double-strand break repair via homologous recombination	IMP IMP: Inferred from mutant phenotype	25593309	GOA
involved in negative regulation of cell migration	IMP IMP: Inferred from mutant phenotype	27477906	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	25593309	GOA
involved in nervous system development	IMP IMP: Inferred from mutant phenotype	35916866	GOA
involved in positive regulation of transcription elongation by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	26655721	GOA
involved in positive regulation of transcription elongation by RNA polymerase II	IPI IPI: Inferred from physical interaction	30134174	GOA
involved in protein localization to chromatin	IMP IMP: Inferred from mutant phenotype	25593309	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in chromatin	IDA IDA: Inferred from direct assay	25593309	GOA
located in cytoplasm	IMP IMP: Inferred from mutant phenotype	28966017	GOA
located in nucleus	IDA IDA: Inferred from direct assay	27477906	GOA
located in site of DNA damage	IDA IDA: Inferred from direct assay	25593309	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZMYND8 Protein Structure

PHD

Bromodomain

PWWP

DUF3544

zf-MYND

0
200
400
600
800
1000
1186 a.a.

Protein Preferred Names	Protein Names
protein kinase C-binding protein 1	CTCL tumor antigen se14-3

Related Diseases

Diseases	Alias
Lymphoma	Lymphoid Cancer Lymphomas Lymphoid Cancers Lymphoid Neoplasm Lymphoma Nos Nhl - [Non-Hodgkin Lymphoma] Non-Hodgkin Lymphoma Non-Hodgkin Lymphoma, Nos Non-Hodgkin Malignant Lymphoma Nos
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-403538	iZMYND8-34	Inhibitor	98.89%	Unkown
HY-RS16096	ZMYND8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20619	Zmynd8 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27127	Zmynd8 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ZMYND8	RGD	RGD:1309544
Canis familiaris	ZMYND8	VGNC	VGNC:48654
Felis catus	ZMYND8	VGNC	VGNC:83481
Mus musculus	ZMYND8	MGD	MGI:1918025
Macaca mulatta	ZMYND8	VGNC	VGNC:98468
Bos taurus	ZMYND8	VGNC	VGNC:37206