Rbm10 - RNA binding motif protein 10 Gene

Also Known as MINAS-60; E430039K10Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 236732

Summary

Predicted to enable identical protein binding activity and miRNA binding activity. Acts upstream of or within negative regulation of RNA metabolic process; negative regulation of cell population proliferation; and positive regulation of smooth muscle cell apoptotic process. Predicted to be located in nuclear speck. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Is expressed in several structures, including branchial arch; central nervous system; early conceptus; oocyte; and sensory organ. Human ortholog(s) of this gene implicated in TARP syndrome. Orthologous to human RBM10 (RNA binding motif protein 10). [provided by Alliance of Genome Resources, Apr 2022]

Rbm10 Products (6)

mRNA	Protein	Name
NM_001167775.2	NP_001161247.1	RNA-binding protein 10 isoform 2
NM_001167776.2	NP_001161248.1	RNA-binding protein 10 isoform 3
NM_001358903.1	NP_001345832.1	RNA-binding protein 10 isoform 2
NM_001358904.1	NP_001345833.1	RNA-binding protein 10 isoform 4
NM_001358905.1	NP_001345834.1	RNA-binding protein 10 isoform 5
NM_145627.3	NP_663602.1	RNA-binding protein 10 isoform 1

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within 3'-UTR-mediated mRNA stabilization	IDA IDA: Inferred from direct assay	19508861	MGI
acts upstream of or within negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	19508861	MGI
acts upstream of or within negative regulation of mRNA splicing, via spliceosome	IMP IMP: Inferred from mutant phenotype	23636947	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19508861	MGI
acts upstream of or within negative regulation of vascular associated smooth muscle cell proliferation	IGI IGI: Inferred from genetic interaction	19508861	MGI
acts upstream of or within positive regulation of vascular associated smooth muscle cell apoptotic process	IDA IDA: Inferred from direct assay	19508861	MGI
acts upstream of or within regulation of vascular associated smooth muscle cell apoptotic process	IGI IGI: Inferred from genetic interaction	19508861	MGI
acts upstream of vascular associated smooth muscle cell apoptotic process	IDA IDA: Inferred from direct assay	19508861	MGI
acts upstream of vascular associated smooth muscle cell proliferation	IGI IGI: Inferred from genetic interaction	19508861	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
RNA-binding protein 10	Ribosome biogenesis inhibitor MINAS-60

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-142032	RBM10-8	Inhibitor	/	Unkown
HY-RS11731	RBM10 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22768	Rbm10 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29282	Rbm10 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rbm10	NCBI	NCBI:8241