Fbln5 - fibulin 5 Gene

Also Known as A55; EVEC; DANCE

Species: Mus musculus

Gene Type: protein coding
Gene ID: 23876

Summary

Enables Integrin binding activity. Involved in several processes, including elastic fiber assembly; intramembranous bone growth; and regulation of transcription by RNA polymerase II. Acts upstream of or within extracellular matrix organization. Located in extracellular space. Colocalizes with collagen-containing extracellular matrix and elastic fiber. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; embryo mesenchyme; and skeleton. Used to study cutis laxa. Human ortholog(s) of this gene implicated in age related macular degeneration; autosomal dominant cutis laxa 2; autosomal recessive cutis laxa type IA; and cutis laxa. Orthologous to human FBLN5 (fibulin 5). [provided by Alliance of Genome Resources, Apr 2022]

Fbln5 Products (13)

mRNA Protein Name
NM_001361987.2 NP_001348916.1 fibulin-5 isoform 1 precursor
NM_001413776.1 NP_001400705.1 fibulin-5 isoform 3 precursor
NM_001413777.1 NP_001400706.1 fibulin-5 isoform 4 precursor
NM_001413778.1 NP_001400707.1 fibulin-5 isoform 5 precursor
NM_001413779.1 NP_001400708.1 fibulin-5 isoform 6 precursor
NM_001413780.1 NP_001400709.1 fibulin-5 isoform 7 precursor
NM_001413781.1 NP_001400710.1 fibulin-5 isoform 8 precursor
NM_001413782.1 NP_001400711.1 fibulin-5 isoform 9 precursor
NM_001413783.1 NP_001400712.1 fibulin-5 isoform 10 precursor
NM_001413784.1 NP_001400713.1 fibulin-5 isoform 1 precursor
NM_001413785.1 NP_001400714.1 fibulin-5 isoform 12
NM_001413786.1 NP_001400715.1 fibulin-5 isoform 12
NM_011812.5 NP_035942.1 fibulin-5 isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables integrin binding IDA
IDA: Inferred from direct assay
11805835 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
14745449 MGI
Biological Process GO Annotation Evidence References Source
involved in elastic fiber assembly IMP
IMP: Inferred from mutant phenotype
11805834 MGI
acts upstream of or within extracellular matrix organization IDA
IDA: Inferred from direct assay
18757743 MGI
involved in intramembranous bone growth IMP
IMP: Inferred from mutant phenotype
26399686 MGI
involved in negative regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
17607303 MGI
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
17607303 MGI
involved in positive regulation of osteoblast proliferation IMP
IMP: Inferred from mutant phenotype
26399686 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
17607303 MGI
involved in protein localization to cell surface IMP
IMP: Inferred from mutant phenotype
15528465 MGI
involved in regulation of removal of superoxide radicals IMP
IMP: Inferred from mutant phenotype
15528465 MGI
Cellular Component GO Annotation Evidence References Source
colocalizes with collagen-containing extracellular matrix IDA
IDA: Inferred from direct assay
15528465 MGI
colocalizes with elastic fiber IDA
IDA: Inferred from direct assay
11805834 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
14745449 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

fibulin-5

  • FIBL-5

  • developmental arteries and neural crest EGF-like protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04774 FBLN5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22501 Fbln5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29023 Fbln5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fbln5 NCBI NCBI:10516