Impdh1 - inosine monophosphate dehydrogenase 1 Gene

Also Known as IMPDH-I; B930086D20Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 23917

Summary

Enables IMP dehydrogenase activity. Involved in 'de novo' XMP biosynthetic process and GMP biosynthetic process. Acts upstream of or within lymphocyte proliferation and purine nucleotide biosynthetic process. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm. Is expressed in central nervous system and retina outer nuclear layer. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 11; retinitis pigmentosa; and retinitis pigmentosa 10. Orthologous to human IMPDH1 (inosine monophosphate dehydrogenase 1). [provided by Alliance of Genome Resources, Apr 2022]

Impdh1 Products (3)

mRNA Protein Name
NM_001302933.1 NP_001289862.1 inosine-5'-monophosphate dehydrogenase 1 isoform 1
NM_001302934.1 NP_001289863.1 inosine-5'-monophosphate dehydrogenase 1 isoform 2
NM_011829.3 NP_035959.2 inosine-5'-monophosphate dehydrogenase 1 isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables IMP dehydrogenase activity IDA
IDA: Inferred from direct assay
12944494 MGI
Biological Process GO Annotation Evidence References Source
involved in 'de novo' XMP biosynthetic process IMP
IMP: Inferred from mutant phenotype
12944494 MGI
involved in GMP biosynthetic process IMP
IMP: Inferred from mutant phenotype
12944494 MGI
acts upstream of or within lymphocyte proliferation IMP
IMP: Inferred from mutant phenotype
12944494 MGI
acts upstream of or within purine nucleotide biosynthetic process IMP
IMP: Inferred from mutant phenotype
12944494 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

inosine-5'-monophosphate dehydrogenase 1

  • IMP dehydrogenase 1

  • IMPD 1

  • IMPDH 1

  • inosine 5'-phosphate dehydrogenase 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-118917 VX-148 Inhibitor / Unkown
HY-147342 β-Benzamide adenine dinucleotide Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Impdh1 NCBI NCBI:3614