Papss2 - 3'-phosphoadenosine 5'-phosphosulfate synthase 2 Gene

Also Known as bm; Sk2; AtpsU2; Atpsk2; 1810018P12Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 23972

Summary

Enables adenylylsulfate kinase activity and sulfate adenylyltransferase (ATP) activity. Acts upstream of or within blood coagulation; bone development; and sulfate assimilation. Is expressed in several structures, including genitourinary system; heart; limb; sensory organ; and skeleton. Used to study spondyloepimetaphyseal dysplasia, Pakistani type. Human ortholog(s) of this gene implicated in spondyloepimetaphyseal dysplasia, Pakistani type. Orthologous to human PAPSS2 (3'-phosphoadenosine 5'-phosphosulfate synthase 2). [provided by Alliance of Genome Resources, Apr 2022]

Papss2 Products (3)

mRNA Protein Name
NM_001201470.1 NP_001188399.1 bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform 2
NM_001360403.1 NP_001347332.1 bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform 3
NM_011864.3 NP_035994.2 bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables adenylylsulfate kinase activity IDA
IDA: Inferred from direct assay
10559207 MGI
enables adenylylsulfate kinase activity IMP
IMP: Inferred from mutant phenotype
230515 MGI
enables sulfate adenylyltransferase (ATP) activity IDA
IDA: Inferred from direct assay
10559207 MGI
enables sulfate adenylyltransferase (ATP) activity IMP
IMP: Inferred from mutant phenotype
230515 MGI
Biological Process GO Annotation Evidence References Source
involved in 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process IDA
IDA: Inferred from direct assay
10559207 MGI
involved in 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process IMP
IMP: Inferred from mutant phenotype
9671738 MGI
acts upstream of or within blood coagulation IMP
IMP: Inferred from mutant phenotype
8835524 MGI
acts upstream of or within bone development IMP
IMP: Inferred from mutant phenotype
624676 MGI
acts upstream of or within sulfate assimilation IDA
IDA: Inferred from direct assay
10559207 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2

  • PAPS synthase 2

  • brachymorphic

  • sulfurylase kinase 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10031 PAPSS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20576 Papss2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27084 Papss2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Papss2 NCBI NCBI:9060