Med24 - mediator complex subunit 24 Gene

Also Known as Gse2; 911GSE; Pparb2; Thrap4; DRIP100; Pparbp2; Trap100; D11Ertd307e

Species: Mus musculus

Gene Type: protein coding
Gene ID: 23989

Summary

This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. The product of this gene may form a submodule of the mediator complex that magnifies the effects of activators on the general transcription machinery. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2008]

Med24 Products (6)

mRNA Protein Name
NM_001361993.2 NP_001348922.1 mediator of RNA polymerase II transcription subunit 24 isoform 1
NM_001361994.2 NP_001348923.1 mediator of RNA polymerase II transcription subunit 24 isoform 1
NM_001361995.2 NP_001348924.1 mediator of RNA polymerase II transcription subunit 24 isoform 2
NM_001378926.1 NP_001365855.1 mediator of RNA polymerase II transcription subunit 24 isoform 1
NM_001378927.1 NP_001365856.1 mediator of RNA polymerase II transcription subunit 24 isoform 2
NM_011869.3 NP_035999.2 mediator of RNA polymerase II transcription subunit 24 isoform 2

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within somatic stem cell population maintenance IMP
IMP: Inferred from mutant phenotype
20720539 MGI
acts upstream of or within transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
12093747 MGI
Cellular Component GO Annotation Evidence References Source
part of mediator complex IDA
IDA: Inferred from direct assay
12093747 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mediator of RNA polymerase II transcription subunit 24

  • genetic suppressor element 2

  • mTRAP100

  • peroxisome proliferation activation receptor binding protein 2

  • thyroid hormone receptor associated protein 4

  • thyroid hormone receptor-associated protein 100 kDa

  • thyroid hormone receptor-associated protein complex

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16294 Med24 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08293 MED22 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08295 MED24 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Med24 NCBI NCBI:9862