Syngap1 - synaptic Ras GTPase activating protein 1 homolog (rat) Gene

Also Known as Gm1963; Syngap

Species: Mus musculus

Gene Type: protein coding
Gene ID: 240057

Summary

This gene encodes a Ras GTPase activating protein that is a member of the N-methyl-D-aspartate receptor complex. The N-terminal domain of the protein contains a Ras-GAP domain, a pleckstrin homology domain, and a C2 domain that may be involved in binding of calcium and Phospholipids. The C-terminal domain consists of a ten histidine repeat region, serine and tyrosine phosphorylation sites, and a T/SXV motif required for postsynaptic scaffold protein interaction. The encoded protein negatively regulates Ras, Rap and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor trafficking to the postsynaptic membrane to regulate synaptic plasticity and neuronal homeostasis. Homozygous null mutations result in early post-embryonic lethality, while heterozygous mutant mice display a variety of phenotypes that include learning and memory defects, hyperactivity, and audiogenic seizures. [provided by RefSeq, Nov 2016]

Syngap1 Products (4)

mRNA Protein Name
NM_001281491.2 NP_001268420.1 ras/Rap GTPase-activating protein SynGAP isoform 1
NM_001371033.1 NP_001357962.1 ras/Rap GTPase-activating protein SynGAP isoform 2
NM_001371034.1 NP_001357963.1 ras/Rap GTPase-activating protein SynGAP isoform 3
NM_001394027.1 NP_001380956.1 ras/Rap GTPase-activating protein SynGAP isoform 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTPase activator activity IDA
IDA: Inferred from direct assay
15014045 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15014045 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within Ras protein signal transduction IDA
IDA: Inferred from direct assay
15014045 MGI
acts upstream of axonogenesis IDA
IDA: Inferred from direct assay
15014045 MGI
acts upstream of or within dendrite development IMP
IMP: Inferred from mutant phenotype
15470153 MGI
involved in maintenance of postsynaptic specialization structure IDA
IDA: Inferred from direct assay
27565345 MGI
involved in maintenance of postsynaptic specialization structure IMP
IMP: Inferred from mutant phenotype
27565345 MGI
involved in modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
27565345 MGI
involved in modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
27565345 MGI
acts upstream of or within negative regulation of axonogenesis IDA
IDA: Inferred from direct assay
15014045 MGI
acts upstream of or within negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
15733080 MGI
acts upstream of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
15733080 MGI
acts upstream of or within pattern specification process IMP
IMP: Inferred from mutant phenotype
16452659 MGI
acts upstream of or within receptor clustering IMP
IMP: Inferred from mutant phenotype
12598599 MGI
acts upstream of or within regulation of MAPK cascade IMP
IMP: Inferred from mutant phenotype
12427827 MGI
acts upstream of or within regulation of long-term neuronal synaptic plasticity IGI
IGI: Inferred from genetic interaction
12427827 MGI
acts upstream of or within regulation of long-term neuronal synaptic plasticity IMP
IMP: Inferred from mutant phenotype
12427827 MGI
acts upstream of or within regulation of synapse structure or activity IMP
IMP: Inferred from mutant phenotype
15470153 MGI
acts upstream of or within visual learning IMP
IMP: Inferred from mutant phenotype
12427827 MGI
Cellular Component GO Annotation Evidence References Source
located in dendritic shaft IDA
IDA: Inferred from direct assay
16452659 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
27565345 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
27565345 MGI
located in membrane IDA
IDA: Inferred from direct assay
15014045 MGI
located in postsynaptic density IDA
IDA: Inferred from direct assay
17114649 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ras/Rap GTPase-activating protein SynGAP

  • neuronal RasGAP

  • ras GTPase-activating protein SynGAP

  • synaptic Ras GTPase-activating protein 1

  • synaptic Ras-GAP 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-180779 SR-1815 / Unkown
HY-RS14089 SYNGAP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20656 Syngap1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27167 Syngap1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Syngap1 NCBI NCBI:8831