2. Gene
  3. Scn11a - sodium channel, voltage-gated, type XI, alpha Gene

Scn11a - sodium channel, voltage-gated, type XI, alpha Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as NaN; NaT; NSS2; SNS2; NaV1.9

Gene ID: 24046 | Gene type: protein coding

About Scn11a

Chromosome 9: 119,582,825-119,654,522 reverse strand.GRCm39:CM001002.3

This gene has 2 transcripts (splice variants), 96 orthologues, 26 paralogues and is associated with 14 phenotypes. Low expression observed in reference dataset.

Summary

Enables voltage-gated Sodium Channel activity. Involved in regulation of sensory perception of pain. Acts upstream of or within sodium ion transport. Located in C-fiber and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; immune system; liver and biliary system; and reproductive system. Used to study familial episodic pain syndrome 3 and hereditary sensory neuropathy. Human ortholog(s) of this gene implicated in familial episodic pain syndrome 3 and hereditary sensory and autonomic neuropathy type 7. Orthologous to human SCN11A (sodium voltage-gated channel alpha subunit 11). [provided by Alliance of Genome Resources, Apr 2022]

Scn11a Products(1)

mRNA Protein Name
NM_011887.3 NP_036017.3 sodium channel protein type 11 subunit alpha

Scn11a Protein Structure

Ion_trans

Ion_trans: pfam00520 (127 - 406)

Ion_trans

Ion_trans: pfam00520 (573 - 807)

Na_trans_assoc

Na_trans_assoc: pfam06512 (811 - 1029)

Ion_trans

Ion_trans: pfam00520 (1033 - 1297)

Na_channel_gate

Na_channel_gate: cd13433 (1289 - 1341)

Ion_trans

Ion_trans: pfam00520 (1345 - 1594)

GPHH

GPHH: cl25190 (1605 - 1652)

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  • 1765 a.a.
Protein Preferred Names Protein Names

sodium channel protein type 11 subunit alpha

sensory neuron sodium channel 2

sodium channel protein type XI subunit alpha

sodium channel, voltage-gated, type XI, alpha polypeptide

voltage-gated sodium channel NAV1.9b

voltage-gated sodium channel subunit alpha Nav1.9

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12522 SCN11A Human Pre-designed siRNA Set A / Unkown
HY-RS12523 Scn11a Mouse Pre-designed siRNA Set A / Unkown
HY-RS12524 Scn11a Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Scn11a NCBI NCBI:11280