Acadm - acyl-CoA dehydrogenase medium chain Gene

Also Known as MCAD

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24158

Summary

Enables several functions, including acyl-CoA dehydrogenase activity; identical protein binding activity; and nucleotide binding activity. Involved in several processes, including fatty acid catabolic process; response to copper ion; and response to glucocorticoid. Located in mitochondrial matrix and mitochondrial membrane. Biomarker of non-alcoholic fatty liver disease. Human ortholog(s) of this gene implicated in medium chain acyl-CoA dehydrogenase deficiency. Orthologous to human ACADM (acyl-CoA dehydrogenase medium chain). [provided by Alliance of Genome Resources, Apr 2022]

Acadm Products (1)

mRNA Protein Name
NM_016986.2 NP_058682.2 medium-chain specific acyl-CoA dehydrogenase, mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables acyl-CoA dehydrogenase activity IDA
IDA: Inferred from direct assay
3968063 RGD
enables flavin adenine dinucleotide binding IDA
IDA: Inferred from direct assay
3968063 RGD
enables identical protein binding IDA
IDA: Inferred from direct assay
3813556 RGD
enables isomerase activity IDA
IDA: Inferred from direct assay
15850406 RGD
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
3968063 RGD
Biological Process GO Annotation Evidence References Source
involved in fatty acid beta-oxidation using acyl-CoA dehydrogenase IDA
IDA: Inferred from direct assay
3968063 RGD
involved in medium-chain fatty acid catabolic process IDA
IDA: Inferred from direct assay
3968063 RGD
involved in response to copper ion IEP
IEP: Inferred from expression pattern
10958805 RGD
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
8615829 RGD
involved in response to hormone IEP
IEP: Inferred from expression pattern
9164869 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
15863369 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
15852996 RGD
Cellular Component GO Annotation Evidence References Source
located in mitochondrial matrix IDA
IDA: Inferred from direct assay
3813556 RGD
located in mitochondrial membrane IDA
IDA: Inferred from direct assay
3813556 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

medium-chain specific acyl-CoA dehydrogenase, mitochondrial

  • Acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight-chain

  • acyl-CoA dehydrogenase, C-4 to C-12 straight chain

  • acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain

  • acyl-Coenzyme A dehydrogenase, medium chain

  • medium-chain acyl-CoA dehydrogenase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00128 ACADM Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17544 Acadm Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24002 Acadm Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Acadm NCBI NCBI:34