Tspo - translocator protein Gene

Also Known as MBR; Bzrp; Ptbzr; PTBZR02; RATPTBZR02

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24230

Summary

Enables androgen binding activity and benzodiazepine receptor activity. Involved in several processes, including cellular response to zinc ion; neurogenesis; and positive regulation of cell death. Located in mitochondrial outer membrane. Used to study Cholesterol ester storage disease. Orthologous to human TSPO (translocator protein). [provided by Alliance of Genome Resources, Apr 2022]

Tspo Products (1)

mRNA Protein Name
NM_012515.2 NP_036647.1 translocator protein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables androgen binding IDA
IDA: Inferred from direct assay
8918981 RGD
enables benzodiazepine receptor activity IDA
IDA: Inferred from direct assay
2555358 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
17174393 RGD
Biological Process GO Annotation Evidence References Source
involved in adrenal gland development IEP
IEP: Inferred from expression pattern
9927316 RGD
involved in behavioral response to pain IMP
IMP: Inferred from mutant phenotype
19555675 RGD
involved in cellular hypotonic response IEP
IEP: Inferred from expression pattern
18709649 RGD
involved in cellular response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
14678758 RGD
involved in cellular response to zinc ion IEP
IEP: Inferred from expression pattern
18709649 RGD
involved in chloride transport IDA
IDA: Inferred from direct assay
14726306 RGD
involved in cholesterol homeostasis IMP
IMP: Inferred from mutant phenotype
29074640 RGD
involved in contact inhibition IDA
IDA: Inferred from direct assay
18190798 RGD
involved in glial cell migration IDA
IDA: Inferred from direct assay
18190798 RGD
involved in monoatomic ion transport IDA
IDA: Inferred from direct assay
14726306 RGD
involved in negative regulation of corticosterone secretion IMP
IMP: Inferred from mutant phenotype
29074640 RGD
involved in negative regulation of glial cell proliferation IDA
IDA: Inferred from direct assay
14678758 RGD
involved in negative regulation of nitric oxide biosynthetic process IDA
IDA: Inferred from direct assay
14678758 RGD
involved in negative regulation of tumor necrosis factor production IDA
IDA: Inferred from direct assay
14678758 RGD
involved in peripheral nervous system axon regeneration IEP
IEP: Inferred from expression pattern
8977149 RGD
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
15284300 RGD
involved in positive regulation of calcium ion transport IMP
IMP: Inferred from mutant phenotype
17174393 RGD
involved in positive regulation of glial cell proliferation IDA
IDA: Inferred from direct assay
18190798 RGD
involved in positive regulation of mitochondrial depolarization IDA
IDA: Inferred from direct assay
15183124 RGD
involved in positive regulation of programmed necrotic cell death IMP
IMP: Inferred from mutant phenotype
15284300 RGD
involved in positive regulation of reactive oxygen species metabolic process IDA
IDA: Inferred from direct assay
12437594 RGD
involved in regulation of steroid biosynthetic process IMP
IMP: Inferred from mutant phenotype
9974124 RGD
involved in response to acetylcholine IMP
IMP: Inferred from mutant phenotype
29074640 RGD
involved in response to axon injury IEP
IEP: Inferred from expression pattern
15255978 RGD
involved in response to manganese ion IEP
IEP: Inferred from expression pattern
12946575 RGD
involved in response to pain IEP
IEP: Inferred from expression pattern
19555675 RGD
involved in response to progesterone IEP
IEP: Inferred from expression pattern
8201845 RGD
involved in response to testosterone IEP
IEP: Inferred from expression pattern
8201845 RGD
involved in response to vitamin B1 IEP
IEP: Inferred from expression pattern
10517697 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
17561380 RGD
involved in steroid biosynthetic process IMP
IMP: Inferred from mutant phenotype
9405411 RGD
Cellular Component GO Annotation Evidence References Source
located in mitochondrial outer membrane IDA
IDA: Inferred from direct assay
19863077 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

translocator protein

  • Benzodiazepin receptor (peripheral)

  • PBR

  • PKBS

  • benzodiazepine receptor, peripheral

  • mitochondrial benzodiazepine receptor

  • peripheral-type benzodiazepine receptor

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-15527 Emapunil Inhibitor 99.94% Phase 2
HY-111191 ONO-2952 99.51% Phase 2
HY-122607 DPA-714 99.86% Phase 2
HY-19854 TRO-40303 / Phase 2

Pre-clinical Phase

Bioactive Molecules (21)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-19567 PK 11195 Inhibitor 99.91% Unkown
HY-153248 PBR28 98.91% Unkown
HY-400882 Tosylate-DPA-714 Ligand 98.78% Unkown
HY-148833 MDM2-p53-IN-16 Inhibitor 99.08% Unkown
HY-150407 TSPO ligand-1 Inducer 98.0% Unkown
HY-RS15177 TSPO Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W782122 Photoclick cholesterol 99.9% Unkown
HY-111191A (R)-ONO-2952 99.81% Unkown
HY-141804 ER176 99.77% Unkown
HY-150409 TSPO ligand-2 Ligand 99.63% Unkown
HY-169964 TSPO/Carbonic Anhydrase Modulator 1 Modulator / Unkown
HY-147225 TSPO Ligand-Linker Conjugates 1 Activator / Unkown
HY-150410 TSPO ligand-3 / Unkown
HY-172534 BPN-01 Substrate / Unkown
HY-175340 Kv7.2/Kv7.3 activator-3 Activator / Unkown
HY-186105A (-)-P7C3-S243 Inhibitor / Unkown
HY-RS15178 TSPO2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W634748 Desalkylgidazepam Agonist / Unkown
HY-RS16721 Tspo Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23157 Tspo Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-122607S DPA-714-d10 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tspo NCBI NCBI:706