Gnb1 - G protein subunit beta 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24400

Summary

Enables alkylglycerophosphoethanolamine phosphodiesterase activity and spectrin binding activity. Involved in G protein-coupled receptor signaling pathway and positive regulation of cytosolic calcium ion concentration. Acts upstream of or within cardiac muscle cell apoptotic process and cellular response to hypoxia. Located in several cellular components, including cell body; photoreceptor inner segment; and photoreceptor outer segment membrane. Part of heterotrimeric G-protein complex. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; autosomal dominant non-syndromic intellectual disability 42; and myelodysplastic syndrome. Orthologous to human GNB1 (G protein subunit beta 1). [provided by Alliance of Genome Resources, Apr 2022]

Gnb1 Products (1)

mRNA Protein Name
NM_030987.2 NP_112249.2 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables alkylglycerophosphoethanolamine phosphodiesterase activity IDA
IDA: Inferred from direct assay
21812758 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
16530190 RGD
enables spectrin binding IDA
IDA: Inferred from direct assay
23704327 RGD
Biological Process GO Annotation Evidence References Source
involved in G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
9092554 RGD
acts upstream of or within cardiac muscle cell apoptotic process IDA
IDA: Inferred from direct assay
19723622 RGD
acts upstream of or within cellular response to hypoxia IDA
IDA: Inferred from direct assay
19723622 RGD
involved in positive regulation of cytosolic calcium ion concentration IMP
IMP: Inferred from mutant phenotype
9092554 RGD
Cellular Component GO Annotation Evidence References Source
located in cell body IDA
IDA: Inferred from direct assay
9648884 RGD
located in dendrite IDA
IDA: Inferred from direct assay
9648884 RGD
part of heterotrimeric G-protein complex IDA
IDA: Inferred from direct assay
11931744 RGD
located in photoreceptor inner segment IDA
IDA: Inferred from direct assay
11931744 RGD
located in photoreceptor outer segment membrane IDA
IDA: Inferred from direct assay
11931744 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

  • Guanine nucleotide-binding protein beta 1

  • guanine nucleotide binding protein (G protein), beta 1

  • guanine nucleotide binding protein (G protein), beta polypeptide 1

  • guanine nucleotide binding protein, beta 1

  • guanine nucleotide-binding protein, beta-1 s

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05545 GNB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05546 GNB1L Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20745 Gnb1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27257 Gnb1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gnb1 NCBI NCBI:2782