2. Gene
  3. Grm1 - glutamate metabotropic receptor 1 Gene

Grm1 - glutamate metabotropic receptor 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Gprc1a

Gene ID: 24414 | Gene type: protein coding

About Grm1

Primary_assembly 1: 5,058,292-5,453,170 reverse strand.mRatBN7.2:CM026974.1

This gene has 2 transcripts (splice variants), 285 orthologues, 7 paralogues and is associated with 15 phenotypes. Restricted expression toward (RPKM 9.5).

Summary

Enables G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential and Estrogen Receptor binding activity. Involved in several processes, including G protein-coupled glutamate receptor signaling pathway; calcium-mediated signaling; and regulation of glutamatergic synaptic transmission. Located in axon; dendritic spine; and synaptic membrane. Is active in glutamatergic synapse. Is integral component of postsynaptic density membrane. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 13 and spinocerebellar ataxia 44. Orthologous to human GRM1 (glutamate metabotropic receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Grm1 Products(2)

mRNA Protein Name
NM_017011.2 NP_058707.2 metabotropic glutamate receptor 1 isoform alpha precursor
NM_001114330.2 NP_001107802.1 metabotropic glutamate receptor 1 isoform beta precursor

Grm1 Protein Structure

PBP1_mGluR_groupI

PBP1_mGluR_groupI: cd06374 (35 - 509)

NCD3G

NCD3G: pfam07562 (520 - 570)

7tmC_mGluR1

7tmC_mGluR1: cd15449 (590 - 615)

7tmC_mGluR1

7tmC_mGluR1: cd15449 (590 - 839)

7tmC_mGluR1

7tmC_mGluR1: cd15449 (627 - 648)

7tmC_mGluR1

7tmC_mGluR1: cd15449 (657 - 681)

7tmC_mGluR1

7tmC_mGluR1: cd15449 (705 - 725)

7tmC_mGluR1

7tmC_mGluR1: cd15449 (748 - 774)

7tmC_mGluR1

7tmC_mGluR1: cd15449 (782 - 805)

7tmC_mGluR1

7tmC_mGluR1: cd15449 (808 - 833)

GluR_Homer-bdg

GluR_Homer-bdg: pfam10606 (1148 - 1198)

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  • 1199 a.a.
Protein Preferred Names Protein Names

metabotropic glutamate receptor 1

G protein coupled receptor family C group 1 member A

glutamate receptor, metabotropic 1

mGluR1

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05819 GRM1 Human Pre-designed siRNA Set A / Unkown
HY-RS05820 Grm1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS05821 Grm1 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Grm1 NCBI NCBI:2911