Grm1 - glutamate metabotropic receptor 1 Gene

Also Known as Gprc1a

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24414

About Grm1

Primary_assembly 1: 5,058,292-5,453,170 reverse strand.mRatBN7.2:CM026974.1

This gene has 2 transcripts (splice variants), 285 orthologues, 7 paralogues and is associated with 15 phenotypes. Restricted expression toward (RPKM 9.5).

Summary

Enables G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential and Estrogen receptor binding activity. Involved in several processes, including G protein-coupled glutamate receptor signaling pathway; calcium-mediated signaling; and regulation of glutamatergic synaptic transmission. Located in axon; dendritic spine; and synaptic membrane. Is active in glutamatergic synapse. Is integral component of postsynaptic density membrane. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 13 and spinocerebellar ataxia 44. Orthologous to human GRM1 (glutamate metabotropic receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Grm1 Products (2)

mRNA Protein Name
NM_017011.2 NP_058707.2 metabotropic glutamate receptor 1 isoform alpha precursor
NM_001114330.2 NP_001107802.1 metabotropic glutamate receptor 1 isoform beta precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables nuclear estrogen receptor binding IPI
IPI: Inferred from physical interaction
18948402 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
9069287 RGD
Biological Process GO Annotation Evidence References Source
involved in calcium-mediated signaling IDA
IDA: Inferred from direct assay
15229243 RGD
involved in chemical synaptic transmission IEP
IEP: Inferred from expression pattern
12514201 RGD
involved in regulation of synaptic transmission, glutamatergic IDA
IDA: Inferred from direct assay
11530226 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
11530226 RGD
located in dendritic spine IDA
IDA: Inferred from direct assay
18582438 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
8104433 RGD
located in neuron projection IDA
IDA: Inferred from direct assay
15829628 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
15829628 RGD
is active in postsynaptic density membrane IDA
IDA: Inferred from direct assay
8104433 RGD
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
8104433 RGD
located in presynaptic membrane IDA
IDA: Inferred from direct assay
11530226 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Grm1 Protein Structure

PBP1_mGluR_groupI

PBP1_mGluR_groupI: cd06374 (35 - 509)

NCD3G

NCD3G: pfam07562 (520 - 570)

7tmC_mGluR1

7tmC_mGluR1: cd15449 (590 - 615)

7tmC_mGluR1

7tmC_mGluR1: cd15449 (590 - 839)

7tmC_mGluR1

7tmC_mGluR1: cd15449 (627 - 648)

7tmC_mGluR1

7tmC_mGluR1: cd15449 (657 - 681)

7tmC_mGluR1

7tmC_mGluR1: cd15449 (705 - 725)

7tmC_mGluR1

7tmC_mGluR1: cd15449 (748 - 774)

7tmC_mGluR1

7tmC_mGluR1: cd15449 (782 - 805)

7tmC_mGluR1

7tmC_mGluR1: cd15449 (808 - 833)

GluR_Homer-bdg

GluR_Homer-bdg: pfam10606 (1148 - 1198)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1199 a.a.
Protein Preferred Names Protein Names

metabotropic glutamate receptor 1

  • G protein coupled receptor family C group 1 member A

  • glutamate receptor, metabotropic 1

  • mGluR1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05819 GRM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05820 Grm1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05821 Grm1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-180871 GRM1 modulator-1 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Grm1 NCBI NCBI:2911