Mdh1 - malate dehydrogenase 1 Gene

Also Known as KAR; MDL1; Mdhl; Mor2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24551

Summary

This gene encodes an enzyme that catalyzes the NAD/NADH-dependent, reversible oxidation of malate to oxaloacetate in many metabolic pathways, including the citric acid cycle. Two main isozymes are known to exist in eukaryotic cells: one is found in the mitochondrial matrix and the Other in the cytoplasm. This gene encodes the cytosolic isozyme, which plays a key role in the malate-aspartate shuttle that allows malate to pass through the mitochondrial membrane to be transformed into oxaloacetate for further cellular processes. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. [provided by RefSeq, Feb 2016]

Mdh1 Products (2)

mRNA Protein Name
NM_001316877.1 NP_001303806.1 malate dehydrogenase, peroxisomal isoform Mdh1x
NM_033235.2 NP_150238.1 malate dehydrogenase, cytoplasmic isoform Mdh1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables L-malate dehydrogenase (NAD+) activity IDA
IDA: Inferred from direct assay
12351438 RGD
enables NAD binding IDA
IDA: Inferred from direct assay
17447164 RGD
enables malate dehydrogenase activity IDA
IDA: Inferred from direct assay
2820961 RGD
Biological Process GO Annotation Evidence References Source
involved in NAD metabolic process IDA
IDA: Inferred from direct assay
17447164 RGD
involved in NADH metabolic process IDA
IDA: Inferred from direct assay
12351438 RGD
involved in malate metabolic process IDA
IDA: Inferred from direct assay
12351438 RGD
involved in oxaloacetate metabolic process IDA
IDA: Inferred from direct assay
17447164 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

malate dehydrogenase, cytoplasmic

malate dehydrogenase, peroxisomal

  • Malate dehydrogenase-like enzyme

  • aromatic alpha-keto acid reductase

  • cytosolic malate dehydrogenase

  • malate dehydrogenase 1, NAD (soluble)

  • malate dehydrogenase, soluble

Recombinant Mdh1 Proteins

Cat. No. Product Name Accession Purity
HY-P74757 MDH1 Protein, Rat (His) O88989 (M1-A334) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-147791 MDH1-IN-2 Inhibitor 98.70% Unkown
HY-147790 MDH1-IN-1 Inhibitor 99.97% Unkown
HY-W613220 MDH1/2-IN-1 Inhibitor 99.53% Unkown
HY-RS08260 MDH1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16793 Mdh1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17185 Me1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23233 Mdh1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mdh1 NCBI NCBI:4190