Ptprc - protein tyrosine phosphatase, receptor type, C Gene

Also Known as Lca; RT7; CD45; L-CA; T200

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24699

Summary

Enables protein tyrosine Phosphatase activity. Involved in T cell receptor signaling pathway; regulation of gene expression; and response to gamma radiation. Located in cell surface. Is integral component of plasma membrane. Human ortholog(s) of this gene implicated in hepatitis C; multiple sclerosis; severe combined immunodeficiency; and severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, Nk cell-positive. Orthologous to human PTPRC (protein tyrosine Phosphatase receptor type C). [provided by Alliance of Genome Resources, Apr 2022]

Ptprc Products (5)

mRNA Protein Name
NM_001109887.2 NP_001103357.1 receptor-type tyrosine-protein phosphatase C isoform 3 precursor
NM_001109888.2 NP_001103358.1 receptor-type tyrosine-protein phosphatase C isoform 5 precursor
NM_001109889.2 NP_001103359.1 receptor-type tyrosine-protein phosphatase C isoform 2 precursor
NM_001109890.2 NP_001103360.1 receptor-type tyrosine-protein phosphatase C isoform 1 precursor
NM_138507.3 NP_612516.2 receptor-type tyrosine-protein phosphatase C isoform 4 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10814697 RGD
enables protein tyrosine phosphatase activity IGI
IGI: Inferred from genetic interaction
12496963 RGD
Biological Process GO Annotation Evidence References Source
involved in T cell receptor signaling pathway IGI
IGI: Inferred from genetic interaction
12496963 RGD
involved in regulation of gene expression IGI
IGI: Inferred from genetic interaction
12496963 RGD
involved in response to aldosterone IEP
IEP: Inferred from expression pattern
29713904 RGD
involved in response to gamma radiation IDA
IDA: Inferred from direct assay
17290791 RGD
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
10814697 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
3158393 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

receptor-type tyrosine-protein phosphatase C

  • T200 glycoprotein

  • leucocyte common antigen

  • leukocyte common antigen A

  • leukocyte common antigen B

  • protein tyrosine phosphatase, receptor-type, c polypeptide

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11434 PTPRC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18077 Ptprc Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24552 Ptprc Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990495 Anti-PTPRC/CD45 Antibody Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ptprc NCBI NCBI:5788