Clu - clusterin Gene

Also Known as CLI; DAG; APOJ; SGP2; SP40; SGP-2; SP-40; Trpm2; Trpmb; TRPM-2; TRPM2B; RATTRPM2B

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24854

Summary

The protein encoded by this gene is a secreted chaperone that can under some stress conditions also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders.[provided by RefSeq, May 2011]

Clu Products (1)

mRNA Protein Name
NM_053021.3 NP_444180.3 clusterin precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11570883 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to growth factor stimulus IEP
IEP: Inferred from expression pattern
16038898 RGD
involved in endocrine pancreas development IMP
IMP: Inferred from mutant phenotype
16411126 RGD
involved in estrous cycle IEP
IEP: Inferred from expression pattern
11149574 RGD
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
15591223 RGD
involved in negative regulation of neuron apoptotic process IGI
IGI: Inferred from genetic interaction
23164821 RGD
involved in neuron projection morphogenesis IMP
IMP: Inferred from mutant phenotype
16038898 RGD
involved in positive regulation of cell differentiation IMP
IMP: Inferred from mutant phenotype
16411126 RGD
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
15591223 RGD
involved in positive regulation of gene expression IGI
IGI: Inferred from genetic interaction
23164821 RGD
involved in protein stabilization IDA
IDA: Inferred from direct assay
11570883 RGD
involved in response to light stimulus IEP
IEP: Inferred from expression pattern
11803476 RGD
involved in response to potassium ion IEP
IEP: Inferred from expression pattern
12782389 RGD
Cellular Component GO Annotation Evidence References Source
located in aggresome IDA
IDA: Inferred from direct assay
12799419 RGD
located in cytosol IDA
IDA: Inferred from direct assay
16038898 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
11570883 RGD
located in growth cone IDA
IDA: Inferred from direct assay
16038898 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
16038898 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

clusterin

  • dimeric acid glycoprotein

  • sulfated glycoprotein 2

  • testosterone repressed prostate message 2

  • testosterone-repressed prostate message

  • testostrone-repressed prostate message 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02848 CLU Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17319 Clu Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23774 Clu Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Clu NCBI NCBI:1191