Gnas - GNAS complex locus Gene

Also Known as ALEX; SCG6; Gnas1; Gnpas; Nesp55; G-alpha-8

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24896

Summary

This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants have been found for this gene. [provided by RefSeq, Apr 2009]

Gnas Products (6)

mRNA Protein Name
NM_001024823.4 NP_001019994.4 ALEX isoform Alex
NM_001159653.1 NP_001153125.1 SCG6 (secretogranin VI) isoform SCG6 precursor
NM_001159656.1 NP_001153128.1 SCG6 (secretogranin VI) isoform SCG6 precursor
NM_001359867.2 NP_001346796.2 GNAS isoform b
NM_019132.3 NP_062005.1 GNAS isoform GNASL
NM_021845.5 NP_068617.6 GNAS isoform XLas

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables D1 dopamine receptor binding IPI
IPI: Inferred from physical interaction
15798088 RGD
enables G-protein alpha-subunit binding IPI
IPI: Inferred from physical interaction
11447126 RGD
enables G-protein beta-subunit binding IDA
IDA: Inferred from direct assay
12486122 RGD
enables GTP binding IDA
IDA: Inferred from direct assay
21084061 RGD
enables adenylate cyclase activator activity IDA
IDA: Inferred from direct assay
13680124 RGD
enables alkylglycerophosphoethanolamine phosphodiesterase activity IDA
IDA: Inferred from direct assay
21812758 RGD
enables alpha-tubulin binding IDA
IDA: Inferred from direct assay
17705289 RGD
enables beta-2 adrenergic receptor binding IPI
IPI: Inferred from physical interaction
19942860 RGD
enables corticotropin-releasing hormone receptor 1 binding IPI
IPI: Inferred from physical interaction
20548297 RGD
enables insulin-like growth factor receptor binding IPI
IPI: Inferred from physical interaction
19764351 RGD
enables ionotropic glutamate receptor binding IPI
IPI: Inferred from physical interaction
19942860 RGD
enables mu-type opioid receptor binding IDA
IDA: Inferred from direct assay
16967511 RGD
enables mu-type opioid receptor binding IPI
IPI: Inferred from physical interaction
19682558 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
11447126 RGD
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
11447126 RGD
Biological Process GO Annotation Evidence References Source
involved in G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
15687107 RGD
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
15579502 RGD
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
12486122 RGD
involved in adenylate cyclase-activating dopamine receptor signaling pathway IDA
IDA: Inferred from direct assay
18403039 RGD
involved in cellular response to catecholamine stimulus IDA
IDA: Inferred from direct assay
18403039 RGD
involved in cellular response to prostaglandin E stimulus IDA
IDA: Inferred from direct assay
18403039 RGD
involved in negative regulation of blood pressure IMP
IMP: Inferred from mutant phenotype
21895632 RGD
involved in positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
17363453 RGD
involved in positive regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
21303955 RGD
involved in positive regulation of sodium ion transport IMP
IMP: Inferred from mutant phenotype
10381586 RGD
involved in regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
20940042 RGD
Cellular Component GO Annotation Evidence References Source
located in COPI-coated Golgi to ER transport vesicle IDA
IDA: Inferred from direct assay
15749703 RGD
located in cytosol IDA
IDA: Inferred from direct assay
9603988 RGD
located in endosome IDA
IDA: Inferred from direct assay
17010343 RGD
part of heterotrimeric G-protein complex IDA
IDA: Inferred from direct assay
15297467 RGD
located in membrane IDA
IDA: Inferred from direct assay
9603988 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
18539096 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
15297467 RGD
located in recycling endosome IDA
IDA: Inferred from direct assay
15297467 RGD
located in ruffle IDA
IDA: Inferred from direct assay
11447126 RGD
located in sarcolemma IDA
IDA: Inferred from direct assay
15961389 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ALEX

GNAS

SCG6 (secretogranin VI)

  • GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus

  • GNAS complex locus XLas-like

  • adenylate cyclase-stimulating G alpha protein

  • guanine nucleotide binding protein alpha s

  • guanine nucleotide-binding protein G-s, alpha subunit

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (25)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-101508 GNA002 Inhibitor 98.02% Unkown
HY-RS05531 GNA13 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05540 GNAS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05529 GNA11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05530 GNA12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05532 GNA14 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05533 GNA15 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-167993 (R)-GNA-T phosphoramidite / Unkown
HY-177335 (R)-GNA-U phosphoramidite / Unkown
HY-RS17744 Gnas Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19685 Gna14 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20938 Gna13 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22532 Gna15 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24210 Gnas Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26178 Gna14 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27455 Gna13 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29052 Gna15 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W1008609 (R)-GNA-A(Bz) phosphoramidite / Unkown
HY-W1008618 (R)-GNA-C(Bz)-phosphoramidite / Unkown
HY-W1008626 (S)-GNA-U-phosphoramidite 96.35% Unkown
HY-W675848 N4-Bz-C-(S)-GNA phosphoramidite / Unkown
HY-W881216 (S)-GNA-T-phosphoramidite / Unkown
HY-W881217 DMT-iBu-G-(S)-GNA Phosphoramidite / Unkown
HY-W881219 N6-Bz-A-(S)-GNA phosphoramidite 98.0% Unkown
HY-W881463 N4-Ac-C-(S)-GNA phosphoramidite / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gnas NCBI NCBI:2778