Itgam - integrin subunit alpha M Gene

Also Known as Cd11b

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25021

Summary

Predicted to enable several functions, including complement component C3b binding activity; heparan sulfate proteoglycan binding activity; and heparin binding activity. Predicted to contribute to cargo receptor activity. Predicted to be involved in several processes, including endocytosis; positive regulation of myeloid leukocyte mediated immunity; and positive regulation of neuron death. Predicted to act upstream of or within several processes, including activated T cell proliferation; leukocyte migration; and microglia development. Predicted to be located in several cellular components, including external side of plasma membrane; extracellular space; and plasma membrane raft. Predicted to be integral component of membrane. Predicted to be part of Integrin alphaM-beta2 complex. Human ortholog(s) of this gene implicated in lupus nephritis. Orthologous to human ITGAM (Integrin subunit alpha M). [provided by Alliance of Genome Resources, Apr 2022]

Itgam Products (1)

mRNA Protein Name
NM_012711.2 NP_036843.2 integrin alpha-M precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
1672643 RGD
Biological Process GO Annotation Evidence References Source
involved in heterotypic cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
1347308 RGD
involved in response to Gram-positive bacterium IEP
IEP: Inferred from expression pattern
9151199 RGD
involved in response to curcumin IEP
IEP: Inferred from expression pattern
30827313 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
32407868 RGD
involved in response to ischemia IEP
IEP: Inferred from expression pattern
19019197 RGD
involved in response to mechanical stimulus IEP
IEP: Inferred from expression pattern
19457130 RGD
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
11447039 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

integrin alpha-M

  • integrin, alpha M

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-156794 Enzomenib Inhibitor 99.88% Unkown
HY-RS20044 Itgam Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-156794A Enzomenib enantiomer Inhibitor 98.01% Unkown
HY-RS06960 ITGAM Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26547 Itgam Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Itgam NCBI NCBI:3684