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Fyn - FYN proto-oncogene, Src family tyrosine kinase Gene

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 25150

Summary

Enables several functions, including phosphatidylinositol 3-kinase binding activity; protein tyrosine kinase activity; and signaling receptor binding activity. Involved in several processes, including cellular response to organonitrogen compound; negative regulation of cell death; and protein phosphorylation. Located in several cellular components, including mitochondrion; perinuclear endoplasmic reticulum; and postsynaptic density. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in Alzheimer's disease and schizophrenia. Orthologous to human Fyn (Fyn proto-oncogene, Src family tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Fyn Products (1)

mRNA	Protein	Name
NM_012755.2	NP_036887.1	tyrosine-protein kinase Fyn

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables CD4 receptor binding	IPI IPI: Inferred from physical interaction	1372996	RGD
enables CD8 receptor binding	IPI IPI: Inferred from physical interaction	1372996	RGD
enables T cell receptor binding	IDA IDA: Inferred from direct assay	1372996	RGD
enables enzyme binding	IPI IPI: Inferred from physical interaction	12231245	RGD
enables peptide hormone receptor binding	IPI IPI: Inferred from physical interaction	7935483	RGD
enables phosphatidylinositol 3-kinase binding	IDA IDA: Inferred from direct assay	9460655	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	8103744	RGD
enables protein kinase activity	IDA IDA: Inferred from direct assay	12353920	RGD
enables protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	8870703	RGD
enables protein tyrosine kinase activity	IMP IMP: Inferred from mutant phenotype	17526495	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	12618293	RGD
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	1280324	RGD
enables type 5 metabotropic glutamate receptor binding	IPI IPI: Inferred from physical interaction	24012003	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to L-glutamate	IMP IMP: Inferred from mutant phenotype	17526495	RGD
involved in cellular response to glycine	IMP IMP: Inferred from mutant phenotype	17526495	RGD
involved in cellular response to growth factor stimulus	IEP IEP: Inferred from expression pattern	11236902	RGD
involved in cellular response to hydrogen peroxide	IDA IDA: Inferred from direct assay	27525436	RGD
involved in cellular response to peptide hormone stimulus	IEP IEP: Inferred from expression pattern	9460655	RGD
involved in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IMP IMP: Inferred from mutant phenotype	18469807	RGD
involved in negative regulation of hydrogen peroxide biosynthetic process	IMP IMP: Inferred from mutant phenotype	27525436	RGD
involved in negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	18469807	RGD
involved in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	27525436	RGD
involved in peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	9460655	RGD
involved in peptidyl-tyrosine phosphorylation	IMP IMP: Inferred from mutant phenotype	12231245	RGD
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	18469807	RGD
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	12353920	RGD
involved in response to singlet oxygen	IDA IDA: Inferred from direct assay	27525436	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	9551931	RGD

Cellular Component GO Annotation	Evidence	References	Source
is active in dendrite	IDA IDA: Inferred from direct assay	24012003	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	27457929	RGD
located in mitochondrion	IDA IDA: Inferred from direct assay	27525436	RGD
located in nucleus	IDA IDA: Inferred from direct assay	27525436	RGD
located in perinuclear endoplasmic reticulum	IDA IDA: Inferred from direct assay	27525436	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	27525436	RGD
located in postsynaptic density	IDA IDA: Inferred from direct assay	22820466	RGD
is active in postsynaptic density, intracellular component	IDA IDA: Inferred from direct assay	27457929	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
tyrosine-protein kinase Fyn	FYN oncogene related to SRC, FGR, YES p59-Fyn proto-oncogene c-Fyn proto-oncogene tyrosine-protein kinase Fyn

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-157442	GLPG3312	Inhibitor	98.63%	Phase 1

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-176892A	Papaveroline hydrochloride	Inhibitor	99.04%	Unkown
HY-176892	Papaveroline	Inhibitor	/	Unkown
HY-118105	RK-20448	Inhibitor	99.38%	Unkown
HY-180938	Fyn-IN-1	Inhibitor	/	Unkown
HY-183584	ARN25699	Inhibitor	/	Unkown
HY-176194	Antifibrotic agent 1	Inhibitor	/	Unkown
HY-120622	BMS-243117	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fyn	NCBI	NCBI:2534