Tox - thymocyte selection-associated high mobility group box Gene

Also Known as 1700007F02Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 252838

Summary

Enables chromatin DNA binding activity. Involved in several processes, including alpha-beta T cell lineage commitment; positive regulation of DNA demethylation; and regulation of positive thymic T cell selection. Acts upstream of or within hematopoietic or lymphoid organ development and positive regulation of natural killer cell differentiation. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; sensory organ; and skeleton. Orthologous to human TOX (thymocyte selection associated high mobility group box). [provided by Alliance of Genome Resources, Apr 2022]

Tox Products (3)

mRNA	Protein	Name
NM_001377078.1	NP_001364007.1	thymocyte selection-associated high mobility group box protein TOX
NM_001377079.1	NP_001364008.1	thymocyte selection-associated high mobility group box protein TOX
NM_145711.5	NP_663757.3	thymocyte selection-associated high mobility group box protein TOX

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables chromatin DNA binding	IDA IDA: Inferred from direct assay	25527292	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment	IMP IMP: Inferred from mutant phenotype	18195075	MGI
involved in CD4-positive, alpha-beta T cell lineage commitment	IMP IMP: Inferred from mutant phenotype	18195075	MGI
involved in CD8-positive, alpha-beta T cell lineage commitment	IMP IMP: Inferred from mutant phenotype	11850626	MGI
involved in NK T cell lineage commitment	IMP IMP: Inferred from mutant phenotype	18195075	MGI
acts upstream of or within Peyer's patch development	IMP IMP: Inferred from mutant phenotype	20818394	MGI
involved in cerebral cortex neuron differentiation	IMP IMP: Inferred from mutant phenotype	25527292	MGI
acts upstream of or within lymph node development	IMP IMP: Inferred from mutant phenotype	20818394	MGI
acts upstream of or within lymphocyte differentiation	IMP IMP: Inferred from mutant phenotype	20818394	MGI
acts upstream of or within positive regulation of natural killer cell differentiation	IMP IMP: Inferred from mutant phenotype	20818394	MGI
involved in positive regulation of neural precursor cell proliferation	IMP IMP: Inferred from mutant phenotype	25527292	MGI
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	25527292	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	15078895	MGI
involved in regulation of positive thymic T cell selection	IMP IMP: Inferred from mutant phenotype	18195075	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	11850626	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
thymocyte selection-associated high mobility group box protein TOX	thymocyte selection-associated HMG box thymus high mobility group box protein TOX

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-176244	KI-TOX-A3	Inhibitor	99.15%	Unkown
HY-D0876	POPSO		95.0%	Unkown
HY-RS14908	TOX Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14909	TOX2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14910	TOX3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14911	TOX4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17002	Tox Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22349	Tox3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23445	Tox Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28871	Tox3 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tox	NCBI	NCBI:9760