Rapgef4 - Rap guanine nucleotide exchange factor 4 Gene

Also Known as CAMPS; Cgef2; Epac2; CAMP-GEFII

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 252857

Summary

Enables cAMP binding activity and guanyl-nucleotide exchange factor activity. Involved in several processes, including animal organ development; positive regulation of neuronal action potential; and regulation of neurotransmitter receptor localization to postsynaptic specialization membrane. Located in several cellular components, including basolateral plasma membrane; brush border; and distal axon. Part of protein-containing complex. Is active in glutamatergic synapse and postsynaptic density. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human RAPGEF4 (Rap guanine nucleotide exchange factor 4). [provided by Alliance of Genome Resources, Apr 2022]

Rapgef4 Products (2)

mRNA Protein Name
NM_001100642.1 NP_001094112.1 rap guanine nucleotide exchange factor 4
NM_001100642.1 NP_001094112.1 rap guanine nucleotide exchange factor 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cAMP binding IDA
IDA: Inferred from direct assay
9856955 RGD
enables guanyl-nucleotide exchange factor activity IDA
IDA: Inferred from direct assay
9856955 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
15202935 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
19734897 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to nerve growth factor stimulus IEP
IEP: Inferred from expression pattern
25126967 RGD
involved in ganglion development IEP
IEP: Inferred from expression pattern
18583150 RGD
involved in heart development IEP
IEP: Inferred from expression pattern
18697745 RGD
involved in negative regulation of synaptic transmission IDA
IDA: Inferred from direct assay
19734897 RGD
involved in positive regulation of neuronal action potential IMP
IMP: Inferred from mutant phenotype
25126967 RGD
involved in positive regulation of protein secretion IMP
IMP: Inferred from mutant phenotype
25126967 RGD
involved in positive regulation of smooth muscle cell migration IDA
IDA: Inferred from direct assay
18697745 RGD
involved in regulation of dendrite development IMP
IMP: Inferred from mutant phenotype
19734897 RGD
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IDA
IDA: Inferred from direct assay
19734897 RGD
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IMP
IMP: Inferred from mutant phenotype
19734897 RGD
involved in regulation of postsynapse organization IDA
IDA: Inferred from direct assay
19734897 RGD
involved in regulation of postsynapse organization IMP
IMP: Inferred from mutant phenotype
19734897 RGD
involved in response to benzene IEP
IEP: Inferred from expression pattern
15468289 RGD
involved in spinal cord development IEP
IEP: Inferred from expression pattern
18583150 RGD
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
18495799 RGD
located in axon IDA
IDA: Inferred from direct assay
19734897 RGD
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
18495799 RGD
located in brush border IDA
IDA: Inferred from direct assay
18495799 RGD
located in cone cell pedicle IDA
IDA: Inferred from direct assay
19883736 RGD
located in dendrite IDA
IDA: Inferred from direct assay
19734897 RGD
located in dendritic spine IDA
IDA: Inferred from direct assay
19734897 RGD
located in excitatory synapse IDA
IDA: Inferred from direct assay
19734897 RGD
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
19734897 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
19734897 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
19734897 RGD
located in growth cone IDA
IDA: Inferred from direct assay
18583150 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
19883736 RGD
located in photoreceptor inner segment IDA
IDA: Inferred from direct assay
19883736 RGD
located in photoreceptor outer segment IDA
IDA: Inferred from direct assay
19883736 RGD
is active in postsynaptic density IDA
IDA: Inferred from direct assay
19734897 RGD
is active in presynapse EXP
EXP: Inferred from Experiment
19734897 RGD
is active in presynapse IDA
IDA: Inferred from direct assay
19734897 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
19734897 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

rap guanine nucleotide exchange factor 4

  • Rap guanine nucleotide exchange factor (GEF) 4

  • cAMP-regulated guanine nucleotide exchange factor II

  • epac 2

  • exchange factor directly activated by cAMP 2

  • exchange protein directly activated by cAMP 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11663 RAPGEF4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21252 Rapgef4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27769 Rapgef4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rapgef4 NCBI NCBI:11069