Grhl2 - grainyhead like transcription factor 2 Gene

Also Known as BOM; clft3; Tcfcp2l3; 0610015A08Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 252973

Summary

Enables DNA-binding transcription factor activity; chromatin binding activity; and intronic transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including epithelial cell differentiation; neural tube closure; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including animal organ development; embryonic morphogenesis; and face development. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 28 and posterior polymorphous corneal dystrophy 4. Orthologous to human GRHL2 (grainyhead like transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Grhl2 Products (1)

mRNA Protein Name
NM_026496.4 NP_080772.2 grainyhead-like protein 2 homolog

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
20978075 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
25758223 MGI
enables intronic transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
20978075 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
21081122 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within anterior neural tube closure IMP
IMP: Inferred from mutant phenotype
21515572 MGI
acts upstream of or within brain development IMP
IMP: Inferred from mutant phenotype
21377456 MGI
acts upstream of or within camera-type eye development IMP
IMP: Inferred from mutant phenotype
21377456 MGI
acts upstream of or within cardiac ventricle morphogenesis IMP
IMP: Inferred from mutant phenotype
21377456 MGI
acts upstream of or within embryonic cranial skeleton morphogenesis IMP
IMP: Inferred from mutant phenotype
21377456 MGI
acts upstream of or within embryonic digit morphogenesis IMP
IMP: Inferred from mutant phenotype
21377456 MGI
acts upstream of or within embryonic organ development IMP
IMP: Inferred from mutant phenotype
21377456 MGI
involved in epidermis development IMP
IMP: Inferred from mutant phenotype
21081122 MGI
involved in epithelial cell morphogenesis IMP
IMP: Inferred from mutant phenotype
22696678 MGI
acts upstream of or within epithelial cell morphogenesis involved in placental branching IMP
IMP: Inferred from mutant phenotype
25758223 MGI
involved in epithelium migration IMP
IMP: Inferred from mutant phenotype
22955271 MGI
acts upstream of or within face development IMP
IMP: Inferred from mutant phenotype
21377456 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
21262862 MGI
involved in lung epithelial cell differentiation IMP
IMP: Inferred from mutant phenotype
22955271 MGI
acts upstream of or within lung lobe morphogenesis IMP
IMP: Inferred from mutant phenotype
21377456 MGI
acts upstream of or within multicellular organism growth IMP
IMP: Inferred from mutant phenotype
21377456 MGI
acts upstream of or within neural tube closure IMP
IMP: Inferred from mutant phenotype
21262862 MGI
involved in neural tube closure IMP
IMP: Inferred from mutant phenotype
20654612 MGI
acts upstream of or within neural tube development IMP
IMP: Inferred from mutant phenotype
21377456 MGI
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
22955271 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
20978075 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
21377456 MGI
acts upstream of or within respiratory tube development IMP
IMP: Inferred from mutant phenotype
21377456 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
22955271 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

grainyhead-like protein 2 homolog

  • brother of mammalian grainyhead

  • grainyhead like 2

  • grainyhead-like 2

  • grainyheadlike

  • transcription factor CP2-like 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS27463 Grhl2 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Grhl2 NCBI NCBI:79977