Mgp - matrix Gla protein Gene

Also Known as Mglap

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25333

Summary

Enables calcium ion binding activity and calcium-dependent protein binding activity. Involved in several processes, including branching morphogenesis of an epithelial tube; response to calcium ion; and response to glucocorticoid. Located in collagen-containing extracellular matrix; endoplasmic reticulum; and extracellular space. Part of protein-containing complex. Human ortholog(s) of this gene implicated in arteriosclerosis; calcinosis; and myocardial infarction. Orthologous to human MGP (matrix Gla protein). [provided by Alliance of Genome Resources, Apr 2022]

Mgp Products (1)

mRNA Protein Name
NM_012862.2 NP_036994.2 matrix Gla protein precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium ion binding IDA
IDA: Inferred from direct assay
12871556 RGD
enables calcium-dependent protein binding IPI
IPI: Inferred from physical interaction
12871556 RGD
Biological Process GO Annotation Evidence References Source
involved in branching morphogenesis of an epithelial tube IMP
IMP: Inferred from mutant phenotype
15136295 RGD
involved in lung development IMP
IMP: Inferred from mutant phenotype
15136295 RGD
involved in ossification IEP
IEP: Inferred from expression pattern
9718189 RGD
involved in protein-containing complex assembly IPI
IPI: Inferred from physical interaction
12676928 RGD
involved in response to calcium ion IEP
IEP: Inferred from expression pattern
11062022 RGD
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
12754193 RGD
involved in response to hormone IEP
IEP: Inferred from expression pattern
16100044 RGD
involved in response to mechanical stimulus IEP
IEP: Inferred from expression pattern
9718189 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
1757478 RGD
Cellular Component GO Annotation Evidence References Source
located in collagen-containing extracellular matrix IDA
IDA: Inferred from direct assay
11716499 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
12676928 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
12676928 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

matrix Gla protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N5102 D-(+)-Fucose Inducer 99.90% Unkown
HY-RS08414 MGP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17482 Mgp Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23940 Mgp Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mgp NCBI NCBI:4256
Mus musculus Mgp NCBI NCBI:17313