Timp3 - TIMP metallopeptidase inhibitor 3 Gene

Also Known as Timp-3

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25358

Summary

Predicted to enable metalloendopeptidase inhibitor activity; protease binding activity; and zinc ion binding activity. Involved in several processes, including negative regulation of proteolysis; response to estrogen; and response to folic acid. Located in cytoplasm. Human ortholog(s) of this gene implicated in Sorsby's fundus dystrophy; breast carcinoma; and urinary bladder Cancer. Orthologous to human TIMP3 (TIMP metallopeptidase inhibitor 3). [provided by Alliance of Genome Resources, Apr 2022]

Timp3 Products (1)

mRNA Protein Name
NM_012886.3 NP_037018.2 metalloproteinase inhibitor 3 precursor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
28854428 RGD
involved in cellular response to interleukin-6 IEP
IEP: Inferred from expression pattern
25484256 RGD
involved in cellular response to peptide IEP
IEP: Inferred from expression pattern
17555880 RGD
involved in mesenchymal cell differentiation involved in bone development IMP
IMP: Inferred from mutant phenotype
31691506 RGD
involved in negative regulation of proteolysis IMP
IMP: Inferred from mutant phenotype
17532789 RGD
involved in negative regulation of vascular associated smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
28854428 RGD
involved in response to amino acid IEP
IEP: Inferred from expression pattern
17083784 RGD
involved in response to estrogen IEP
IEP: Inferred from expression pattern
15866537 RGD
involved in response to folic acid IEP
IEP: Inferred from expression pattern
18156304 RGD
involved in response to hormone IEP
IEP: Inferred from expression pattern
17275272 RGD
involved in response to mechanical stimulus IEP
IEP: Inferred from expression pattern
17717962 RGD
involved in response to muscle activity IEP
IEP: Inferred from expression pattern
25820551 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
25820551 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
15866537 RGD
involved in tissue regeneration IEP
IEP: Inferred from expression pattern
16683235 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

metalloproteinase inhibitor 3

  • tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory)

  • tissue inhibitor of metalloproteinases 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-145426 MPT0B390 Inhibitor 98.76% Unkown
HY-RS14540 TIMP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18302 Timp3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24780 Timp3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Timp3 NCBI NCBI:7078