Dpysl2 - dihydropyrimidinase-like 2 Gene

Also Known as Crmp2; TOAD-64

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25416

Summary

Predicted to enable identical protein binding activity and protein kinase binding activity. Involved in several processes, including central nervous system development; positive regulation of glutamate secretion; and response to amphetamine. Located in several cellular components, including growth cone; myelin sheath; and neuronal cell body. Part of protein-containing complex. Is active in presynapse. Colocalizes with terminal bouton. Biomarker of brain ischemia; hypothyroidism; and status epilepticus. Orthologous to human DPYSL2 (dihydropyrimidinase like 2). [provided by Alliance of Genome Resources, Apr 2022]

Dpysl2 Products (1)

mRNA Protein Name
NM_001105717.2 NP_001099187.1 dihydropyrimidinase-related protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
9375656 RGD
Biological Process GO Annotation Evidence References Source
involved in olfactory bulb development IEP
IEP: Inferred from expression pattern
14751288 RGD
involved in positive regulation of glutamate secretion IDA
IDA: Inferred from direct assay
19755421 RGD
involved in regulation of neuron differentiation IMP
IMP: Inferred from mutant phenotype
18218617 RGD
involved in regulation of postsynapse assembly IDA
IDA: Inferred from direct assay
29425794 RGD
involved in regulation of postsynapse assembly IMP
IMP: Inferred from mutant phenotype
29425794 RGD
involved in response to amphetamine IEP
IEP: Inferred from expression pattern
20058175 RGD
involved in response to cocaine IEP
IEP: Inferred from expression pattern
19457111 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
12188101 RGD
involved in spinal cord development IEP
IEP: Inferred from expression pattern
8946055 RGD
involved in synaptic vesicle transport IDA
IDA: Inferred from direct assay
19755421 RGD
Cellular Component GO Annotation Evidence References Source
located in dendrite IDA
IDA: Inferred from direct assay
19755421 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
29425794 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
29425794 RGD
located in growth cone IDA
IDA: Inferred from direct assay
7472434 RGD
located in myelin sheath IDA
IDA: Inferred from direct assay
17960831 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
19457111 RGD
is active in presynapse IDA
IDA: Inferred from direct assay
19755421 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
19755421 RGD
is active in synapse IDA
IDA: Inferred from direct assay
19755421 RGD
is active in synapse IMP
IMP: Inferred from mutant phenotype
19755421 RGD
located in terminal bouton IDA
IDA: Inferred from direct assay
19755421 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dihydropyrimidinase-related protein 2

  • CRMP-2

  • DRP-2

  • collapsin response mediator protein 2

  • turned on after division, 64 kDa protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03981 DPYSL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18860 Dpysl2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25352 Dpysl2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dpysl2 NCBI NCBI:1808