P2rx1 - purinergic receptor P2X 1 Gene

Also Known as P2XMR

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 25505

About P2rx1

Primary_assembly 10: 57,618,586-57,633,623 forward strand.mRatBN7.2:CM026983.1

This gene has 3 transcripts (splice variants), 199 orthologues, 6 paralogues and is associated with 1 phenotype. Biased expression in Lung (RPKM 76.9), Spleen (RPKM 54.) and 8 other tissues.

Summary

Enables several functions, including ATP binding activity; extracellularly ATP-gated cation channel activity; and suramin binding activity. Involved in several processes, including glutamatergic synaptic transmission; neuronal action potential; and regulation of cytosolic calcium ion concentration. Located in membrane raft; neuron projection; and plasma membrane. Part of protein-containing complex. Is active in glutamatergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic active zone membrane. Orthologous to human P2RX1 (purinergic receptor P2X 1). [provided by Alliance of Genome Resources, Apr 2022]

P2rx1 Products (3)

mRNA	Protein	Name
NM_001285415.1	NP_001272344.1	P2X purinoceptor 1 isoform 3
NM_001142367.2	NP_001135839.1	P2X purinoceptor 1 isoform 2
NM_012997.3	NP_037129.1	P2X purinoceptor 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP binding	IDA IDA: Inferred from direct assay	16934235	RGD
enables ATP binding	IMP IMP: Inferred from mutant phenotype	17287520	RGD
enables extracellularly ATP-gated monoatomic cation channel activity	IDA IDA: Inferred from direct assay	16934235	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	15313628	RGD
enables nucleotide binding	IDA IDA: Inferred from direct assay	12237343	RGD
enables organic cyclic compound binding	IPI IPI: Inferred from physical interaction	12237343	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	9855626	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	15313628	RGD
enables suramin binding	IDA IDA: Inferred from direct assay	12237343	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in monoatomic cation transmembrane transport	IDA IDA: Inferred from direct assay	7523951	RGD
involved in monoatomic ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	14625300	RGD
involved in neuronal action potential	IDA IDA: Inferred from direct assay	16934235	RGD
involved in positive regulation of calcium ion import across plasma membrane	IDA IDA: Inferred from direct assay	12237343	RGD
involved in regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	14679185	RGD
involved in regulation of presynaptic cytosolic calcium ion concentration	EXP EXP: Inferred from Experiment	16000618	RGD
involved in regulation of presynaptic cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	16000618	RGD
involved in regulation of presynaptic cytosolic calcium ion concentration	IEP IEP: Inferred from expression pattern	16000618	RGD
involved in regulation of synaptic vesicle exocytosis	EXP EXP: Inferred from Experiment	16000618	RGD
involved in regulation of synaptic vesicle exocytosis	IDA IDA: Inferred from direct assay	16000618	RGD
involved in regulation of synaptic vesicle exocytosis	IEP IEP: Inferred from expression pattern	16000618	RGD
involved in synaptic transmission, glutamatergic	IMP IMP: Inferred from mutant phenotype	16000618	RGD

Cellular Component GO Annotation	Evidence	References	Source
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	16000618	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	16000618	RGD
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	26801076	RGD
is active in presynaptic active zone membrane	IDA IDA: Inferred from direct assay	16000618	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	17287520	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

P2rx1 Protein Structure

P2X

0
100
200
300
399 a.a.

Protein Preferred Names	Protein Names
P2X purinoceptor 1	ATP receptor P2X1 RP-2 protein purinergic receptor P2X, ligand-gated ion channel, 1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09897	P2RX1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09898	P2rx1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09899	P2rx1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	P2rx1	NCBI	NCBI:5023