Crem - cAMP responsive element modulator Gene

Also Known as Icer

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25620

Summary

Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including glucose metabolic process; regulation of circadian rhythm; and retinoic acid receptor signaling pathway. Predicted to be located in cytoplasm and nucleus. Predicted to be part of ATF4-CREB1 transcription factor complex. Biomarker of transient cerebral ischemia. Orthologous to human CREM (cAMP responsive element modulator). [provided by Alliance of Genome Resources, Apr 2022]

Crem Products (8)

mRNA Protein Name
NM_001110860.2 NP_001104330.1 cAMP-responsive element modulator isoform 3
NM_001271101.1 NP_001258030.1 cAMP-responsive element modulator isoform 4
NM_001271102.1 NP_001258031.1 cAMP-responsive element modulator isoform 5
NM_001271245.1 NP_001258174.1 cAMP-responsive element modulator isoform 6
NM_001271246.1 NP_001258175.1 cAMP-responsive element modulator isoform 7
NM_001271247.1 NP_001258176.1 cAMP-responsive element modulator isoform 8
NM_001271248.1 NP_001258177.1 cAMP-responsive element modulator isoform 9
NM_017334.2 NP_059030.2 cAMP-responsive element modulator isoform 2

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in fatty acid metabolic process IEP
IEP: Inferred from expression pattern
14534319 RGD
involved in glucose metabolic process IEP
IEP: Inferred from expression pattern
14534319 RGD
involved in retinoic acid receptor signaling pathway IEP
IEP: Inferred from expression pattern
15725648 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cAMP-responsive element modulator

  • CRE modulator

  • cAMP responsive element moderator

  • inducible cyclic AMP early repressor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03165 CREM Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20710 Crem Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27221 Crem Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Crem NCBI NCBI:1390