IRF2BP1 - interferon regulatory factor 2 binding protein 1 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 26145

About IRF2BP1

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:45,883,608-45,886,141 (from NCBI)

This gene has 1 transcript (splice variant), 225 orthologues and 5 paralogues.

Summary

Enables transcription corepressor activity and ubiquitin protein Ligase activity. Involved in protein polyubiquitination. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

IRF2BP1 Products (1)

mRNA Protein Name
NM_015649.3 NP_056464.1 interferon regulatory factor 2-binding protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18671972 GOA
enables transcription corepressor activity IDA
IDA: Inferred from direct assay
12799427 GOA
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
18671972 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12799427 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
18671972 GOA
involved in protein polyubiquitination IDA
IDA: Inferred from direct assay
18671972 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
12799427 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IRF2BP1 Protein Structure

IRF-2BP1_2

IRF-2BP1_2: Interferon regulatory factor 2-binding protein zinc finger (7 - 59)

zf-C3HC4

zf-C3HC4: Zinc finger, C3HC4 type (RING finger) (503 - 547)

  • 0
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  • 200
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  • 500
  • 584 a.a.
Protein Preferred Names Protein Names

interferon regulatory factor 2-binding protein 1

  • IRF-2-binding protein 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06904 IRF2BP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta IRF2BP1 VGNC VGNC:73638
Rattus norvegicus IRF2BP1 RGD RGD:1308312
Canis familiaris IRF2BP1 VGNC VGNC:42093
Mus musculus IRF2BP1 MGD MGI:2442159
Others IRF2BP1 NCBI