GAS2 - growth arrest specific 2 Gene

Also Known as GAS-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2620

About GAS2

Cytogenetic location: 11p14.3 Genomic coordinates (GRCh38): 11:22,626,002-22,885,695 (from NCBI)

This gene has 11 transcripts (splice variants), 280 orthologues and 7 paralogues. Broad expression in liver (RPKM 2.8), kidney (RPKM 0.9) and 21 other tissues.

Summary

The protein encoded by this gene is a Caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during Apoptosis. It can also modulate cell susceptibility to p53-dependent Apoptosis by inhibiting calpain activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2017]

GAS2 Products (9)

mRNA Protein Name
NM_001143830.3 NP_001137302.1 growth arrest-specific protein 2 isoform a
NM_001351224.3 NP_001338153.1 growth arrest-specific protein 2 isoform b
NM_001391933.1 NP_001378862.1 growth arrest-specific protein 2 isoform c
NM_001391934.1 NP_001378863.1 growth arrest-specific protein 2 isoform a
NM_001391935.1 NP_001378864.1 growth arrest-specific protein 2 isoform a
NM_001391936.1 NP_001378865.1 growth arrest-specific protein 2 isoform a
NM_001391937.1 NP_001378866.1 growth arrest-specific protein 2 isoform a
NM_005256.5 NP_005247.1 growth arrest-specific protein 2 isoform a
NM_177553.4 NP_808221.1 growth arrest-specific protein 2 isoform a

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GAS2 Protein Structure

CH

CH: Calponin homology (CH) domain (38 - 155)

GAS2

GAS2: Growth-Arrest-Specific Protein 2 Domain (200 - 273)

  • 0
  • 100
  • 200
  • 313 a.a.
Protein Preferred Names Protein Names

growth arrest-specific protein 2

GAS2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P86887 GAS2 Antibody (YA6580) WB, IHC-P Human, Mouse, Rat

Related Diseases

Diseases Alias
Gnathodiaphyseal Dysplasia

  • GDD

  • Osteogenesis Imperfecta With Unusual Skeletal Lesions

  • Gnathodiaphyseal Sclerosis

  • Osteogenesis Imperfecta, Levin Type

  • Levin Syndrome 2

  • Dysplasia, Gnathodiaphyseal
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-120679 XK469 Inhibitor 98% Unkown
HY-RS05282 GAS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05283 GAS2L1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05284 GAS2L3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-175485 GaSal-2 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus GAS2 VGNC VGNC:62467
Macaca mulatta GAS2 VGNC VGNC:72884
Canis familiaris GAS2 VGNC VGNC:41115
Bos taurus GAS2 VGNC VGNC:29257
Rattus norvegicus GAS2 RGD RGD:1563167
Mus musculus GAS2 MGD MGI:95657
Others GAS2 NCBI