ARL5A - ADP ribosylation factor like GTPase 5A Gene

Also Known as ARL5; ARFLP5

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 26225

About ARL5A

Cytogenetic location: 2q23.3 Genomic coordinates (GRCh38): 2:151,798,797-151,828,421 (from NCBI)

This gene has 7 transcripts (splice variants), 212 orthologues and 30 paralogues. Ubiquitous expression in thyroid (RPKM 27.2), heart (RPKM 19.5) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the ARF family of GTP-binding proteins. With its distinctive nuclear/nucleolar localization and interaction with HP1alpha, the protein is developmentally regulated and may play a role(s) in nuclear dynamics and/or signaling cascades during embryonic development. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008]

ARL5A Products (3)

mRNA	Protein	Name
NM_001037174.2	NP_001032251.1	ADP-ribosylation factor-like protein 5A isoform 2
NM_012097.4	NP_036229.1	ADP-ribosylation factor-like protein 5A isoform 1
NM_177985.3	NP_817114.2	ADP-ribosylation factor-like protein 5A isoform 2

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	References	Source
involved in protein localization to Golgi membrane	IGI IGI: Inferred from genetic interaction	25795912	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARL5A Protein Structure

Arf

0
100
179 a.a.

Protein Preferred Names	Protein Names
ADP-ribosylation factor-like protein 5A	ADP-ribosylation factor-like 5

Related Diseases

Diseases	Alias
Mucinous Stomach Adenocarcinoma	Mucinous Adenocarcinoma Of The Stomach Mucinous Gastric Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00991	ARL5A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ARL5A	VGNC	VGNC:80139
Macaca mulatta	ARL5A	VGNC	VGNC:70017
Canis familiaris	ARL5A	VGNC	VGNC:38115
Bos taurus	ARL5A	VGNC	VGNC:26147
Mus musculus	ARL5A	MGD	MGI:1922673
Rattus norvegicus	ARL5A	RGD	RGD:621327
Others	ARL5A	NCBI