Esrra - estrogen related receptor, alpha Gene

Also Known as Err1; Nr3b1; Estrra; ERRalpha

Species: Mus musculus

Gene Type: protein coding

Gene ID: 26379

About Esrra

Chromosome 19: 6,888,345-6,899,208 reverse strand.GRCm39:CM001012.3

This gene has 6 transcripts (splice variants), 175 orthologues, 8 paralogues and is associated with 45 phenotypes. Broad expression in duodenum adult (RPKM 141.5), small intestine adult (RPKM 86.) and 22 other tissues.

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human ESRRA (estrogen related receptor alpha). [provided by Alliance of Genome Resources, Apr 2022]

Esrra Products (3)

mRNA	Protein	Name
NM_007953.3	NP_031979.2	steroid hormone receptor ERR1 isoform 1
NM_001413229.1	NP_001400158.1	steroid hormone receptor ERR1 isoform 2
NM_001413228.1	NP_001400157.1	steroid hormone receptor ERR1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	18234909	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	18234909	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	18234909	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	18234909	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	21190936	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18234909	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18234909	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18234909	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	21106753	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	18234909	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Esrra Protein Structure

NR_DBD_ERR

NR_LBD_ERR

0
100
200
300
400
422 a.a.

Protein Preferred Names	Protein Names
steroid hormone receptor ERR1	ERR-alpha Steroid hormone receptor ERR1 (Estrogen-related receptor, alpha) (ERR-alpha) (Estrogen receptor-like 1) estrogen receptor related 1 estrogen receptor-like 1 nuclear receptor subfamily 3 group B member 1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04537	ESRRA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04538	Esrra Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04539	Esrra Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Esrra	NCBI	NCBI:2101